Editing Alpha-2-Macroglobulin(a2M)

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Summary	<p>Alpha2-macroglobulin is a major serum protein with diverse functions, including inhibition of protease activity and binding of growth factors, cytokines, and disease factors. It is also a panproteinase inhibitor that is found immunohistochemically in neuritic plaques.</p><p>Alpha-2-macroglobulin is able to inactivate an enormous variety of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). Alpha-2-macroglobulin has in its structure a 35 aminoacid &quot;bait&quot; region. Proteinases binding and cleaving the bait region become bound to alpha2M. The proteinase-&alpha;2M complex is recognised by macrophage receptors and cleared from the system.</p>
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