Apoptosis is a strictly regulated and evolutionarily conserved cell death program, also known for its role as a tumor suppressive mechanism. Apoptosis is a normal physiological cell death response to many stimuli, infections, or injuries, including those caused by cytotoxic drug therapy or radiation therapy regimens, which can result in irreparable DNA damage. The role of apoptosis in cancer has received widespread attention, and resistance to apoptosis is widely recognized as an acquired characteristic of cancer cells, giving them survival advantages, promoting tumor evolution and growth, and leading to treatment failure.Therefore, the efficacy of cancer treatment not only depends str......2024-08-07

Apoptosis is a highly regulated process of cell death, which is an important component of various physiological processes, including normal cell renewal, normal development and function of the immune system, hormone dependent atrophy, embryonic development, and chemically induced cell death. Inappropriate apoptosis is a factor in many human diseases, including neurodegenerative diseases, ischemic injuries, autoimmune diseases, and many types of cancer. With apoptosis becoming the focus of research, the enormous therapeutic potential of apoptosis enables researchers to develop promising therapeutic solutions focused on voluntary death of abnormal cells. Research continues to focus on el......2024-07-30

Diabetic cardiomyopathy (DCM) is a specific form of heart disease caused by the progression of resistance to insulin metabolism in the heart tissue, compensatory hyperinsulinemia, and hyperglycemia, which occurs independently of other cardiac risk factors, such as coronary artery disease and high blood pressure. This form of cardiomyopathy is a major cause of morbidity and mortality in developed countries, and its prevalence is rising with the increasing incidence of obesity and type 2 diabetes. DCM observed in insulin resistance or hyperinsulinemia states is characterized by impaired myocardial insulin signaling, mitochondrial dysfunction, endoplasmic reticulum stress, impaired calciu......2024-07-23

Despite recent therapeutic advancements, ovarian cancer continues to exhibit the highest mortality rate among gynecological malignancies. In most cases, ovarian cancer is managed through repeated cycles of platinum-based chemotherapy. Although tumors initially respond to this treatment, they inevitably develop drug resistance, leading to relapse. The acquisition of drug resistance during therapy has long been viewed as a process entirely confined to the molecular events occurring within cancer cells.However, recent data suggest an interesting scenario where the cancer cell death induced by initial therapy promotes subsequent expansion of the survived clones.During chemotherapy, dying t......2024-07-22

Under normal circumstances, moderate pyroptosis helps to clear infected cells in time, but excessive activation of pyroptosis can lead to massive cell death, serious tissue damage and organ failure, which is related to the pathogenesis of some diseases. Nowadays, due to the increasing incidence of liver disease, it has become a serious health problem in the world. Some of them progress to cirrhosis and hepatocellular carcinoma (HCC), which is a serious threat to human life. Studies have shown that pyroptosis is one of the causes of liver disease development. Due to the presence of gut-liver axis in the body, when the gut microbiota is imbalanced, the gut microbiota can enter the liver.......2024-07-22

Sleep is a natural and reversible state, mainly controlled by neurobiological processes, and is an essential physiological part of human life to maintain health. Sleep has a multifaceted impact on the body, reducing energy expenditure, increasing the recovery of energy stores in the brain, regulating adaptive and innate immune responses, and helping to consolidate memories. Sleep quality is affected by many factors, such as diet, physical activity, genetic and environmental factors. Sleep disorder is a very common disease, which disturbs the normal circadian rhythm and has a negative impact on mental and physical health.Sleep disorders are associated with the occurrence and development......2024-04-09