Editing Eukaryotic Translation Initiation Factor 2C4(EIF2C4)

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Summary	EIF2C4 encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. The deduced 924-amino acid protein shares 80% identity with rabbit translation initiation factor Eif2c. RT-PCR followed by ELISA revealed intermediate and nearly uniform levels of expression in all tissues and specific brain regions tested.
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