Editing Purinergic Receptor P2X, Ligand Gated Ion Channel 1(P2RX1)

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Summary	P2X purinoceptor 1 is a protein belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.The sequence of the predicted 399-amino acid human protein is 89% identical to that of the rat and mouse homologs.
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