Editing Phosphatidylinositol-4-Phosphate-5-Kinase Type I Beta(PIP5K1b)

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Summary	STM7 gene contains 17 exons and spans more than 300 kb.Expression was found to be complex, with multiple transcripts detected in a variety of tissues and evidence of alternative splicing and developmental control. The predicted amino acid sequence for the 2.7-kb transcript showed a marked homology to the deduced amino acid sequence of the MSS4 protein of Saccharomyces cerevisiae, which had been proposed to function in the phosphoinositide cycle, thus suggesting a potential role for the human homolog in signal transduction. Although no evidence of mutation was detected in the transcript, the sequence represented only one of the shorter alternatively spliced species identified by Northern analysis and direct sequencing.
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