Editing Nascent Polypeptide Associated Complex Alpha 1(NACa1)

Content that violates any copyrights will be deleted. The content must be verifiable. Work submitted to CLOUD-CLONE can be edited, used, and redistributed — by anyone — subject to certain terms and conditions.

Item Name
Abbreviation
Synonyms
CAS
HGNC
MGI
PubMed
RGD
UniProt
Wiki
Summary	Wiedmann et al. (1994) purified the heterodimeric nascent polypeptide-associated complex (NAC) from bovine cytosol and determined that it contains Naca, which migrated at an apparent molecular mass of about 33 kD, and Btf3b, which migrated at an apparent molecular mass of about 21 kD. Using peptide sequences from the purified proteins, they cloned human NACA and BTF3B. NAC did not bind to fully emerged signal peptides. In the absence of NAC, the signal recognition particle (SRP) interacted with polypeptides even in the absence of a signal peptide and allowed mistargeting of the protein to the SRP receptor at the endoplasmic reticulum membrane. Readdition of purified NAC prevented mistranslocation.
Contacts	(Please send us your contacts, e.g.: email@google.com and your other information)
More advices
CheckCode