Editing Guanylate Cyclase 1 Beta 3(GUCY1b3)

Content that violates any copyrights will be deleted. The content must be verifiable. Work submitted to CLOUD-CLONE can be edited, used, and redistributed — by anyone — subject to certain terms and conditions.

Item Name
Abbreviation
Synonyms
CAS
HGNC
MGI
PubMed
RGD
UniProt
Wiki
Summary	Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs. NOGC had been considered a soluble enzyme, but evidence that the alpha-2 subunit of the alpha-2/beta-1 isoform interacts with the PDZ domain of PSD95 (DLG4) suggests that the alpha-2 subunit directs a membrane association of this isoform. The interaction with PSD95 locates the alpha-2/beta-1 isoform in close proximity to the NO-generating NO synthase (NOS1), thereby enabling the NO sensor to respond to locally raised NO concentrations.
Contacts	(Please send us your contacts, e.g.: email@google.com and your other information)
More advices
CheckCode