Editing LEO1, Paf1/RNA Polymerase II Complex Component, Homolog(LEO1)

Content that violates any copyrights will be deleted. The content must be verifiable. Work submitted to CLOUD-CLONE can be edited, used, and redistributed — by anyone — subject to certain terms and conditions.

Item Name
Abbreviation
Synonyms
CAS
HGNC
MGI
PubMed
RGD
UniProt
Wiki
Summary	LEO1, parafibromin (CDC73), CTR9, and PAF1 form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. The deduced 666-amino acid protein has an N-terminal AAA domain and a C-terminal domain that shares a high degree of similarity with yeast Leo1. LEO1 has several putative phosphorylation sites and several putative nuclear localization signals in the C terminus. The AAA domain was found in mouse, rat, and human LEO1 proteins but not in yeast, nematode, or fly Leo1 homologs. Northern blot analysis detected a 2.4-kb transcript highly expressed in skeletal muscle and heart, and more weakly expressed in placenta, liver, and other tissues. Fluorescence-tagged LEO1 localized predominantly in the nucleus of transfected human fibroblasts.
Contacts	(Please send us your contacts, e.g.: email@google.com and your other information)
More advices
CheckCode