Editing PIF1 5'-To-3' DNA Helicase Homolog(PIF1)

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Summary	PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase, a reverse transcriptase that maintains telomere length. PIF1 reduced telomerase processivity and unwound telomeric DNA/telomerase RNA (TERC) duplexes in vitro, and it preferentially bound telomeric DNA in vitro and in vivo. PIF1 had a short half life, and its degradation was mediated by ubiquitination and proteasomal degradation. Abundance of PIF1 decreased following overexpression of an activator of the anaphase-promoting complex/cyclosome. PIF1 interacted with the catalytic telomerase subunit, TERT, and telomerase activity immunoprecipitated with PIF1 from human cell lines.
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