Editing Vacuolar Protein Sorting 37C(VPS37C)

Content that violates any copyrights will be deleted. The content must be verifiable. Work submitted to CLOUD-CLONE can be edited, used, and redistributed — by anyone — subject to certain terms and conditions.

Item Name
Abbreviation
Synonyms
CAS
HGNC
MGI
PubMed
RGD
UniProt
Wiki
Summary	VPS37C formed a ternary complex with TSG101 and VPS28 by binding a C-terminal domain of TSG101. VPS37C also bound HRS (HGS), another class E VPS factor. VPS37C was recruited to aberrant endosomes induced by overexpression of TSG101, HRS, or a dominant-negative form of VPS4 (VPS4A). Enveloped viruses that encode PTAP motifs to facilitate budding, like human immunodeficiency virus (HIV)-1 Gag protein, exploit ESCRT-I as an interface with the class E VPS pathway. VPS37C was recruited to the plasma membrane along with TSG101 by HIV-1 Gag. Moreover, direct fusion of VPS37C to HIV-1 Gag obviated the requirement for a PTAP motif to induce virion release. Depletion of VPS37C from human embryonic kidney cells did not inhibit murine leukemia virus budding, which is not mediated by ESCRT-I.
Contacts	(Please send us your contacts, e.g.: email@google.com and your other information)
More advices
CheckCode