Editing Fat Mass And Obesity Associated Protein(FTO)

Content that violates any copyrights will be deleted. The content must be verifiable. Work submitted to CLOUD-CLONE can be edited, used, and redistributed — by anyone — subject to certain terms and conditions.

Item Name
Abbreviation
Synonyms
CAS
HGNC
MGI
PubMed
RGD
UniProt
Wiki
Summary	The predicted 502-amino acid Fto protein has a calculated molecular mass of 58 kD and contains an N-terminal bipartite nuclear localization signal. RT-PCR detected Fto expression throughout mouse embryonic development and in all adult mouse tissues examined except heart and skin. FTO shares sequence motifs with iron- and 2-oxoglutarate (2OG)-dependent oxygenases.Consistent with a potential role in nucleic acid demethylation, Fto localized to the nucleus in transfected cells. Studies of wildtype mice indicated that Fto mRNA is most abundant in the brain, particularly in hypothalamic nuclei governing energy balance, and that Fto mRNA levels in the arcuate nucleus are regulated by feeding and fasting.
Contacts	(Please send us your contacts, e.g.: email@google.com and your other information)
More advices
CheckCode