Editing DBF4 Homolog B(DBF4B)

Content that violates any copyrights will be deleted. The content must be verifiable. Work submitted to CLOUD-CLONE can be edited, used, and redistributed — by anyone — subject to certain terms and conditions.

Item Name
Abbreviation
Synonyms
CAS
HGNC
MGI
PubMed
RGD
UniProt
Wiki
Summary	DBF4B encodes a regulator of the CDC7-like 1 protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and its expression is cell cycle-regulated. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full length sequences have not been determined.The DBF4B-CDC7 protein complex displayed an in vitro kinase activity with a substrate preference for MCM2 and DBF4B itself was a substrate for CDC7. Kinase activity was not detected in CDC7 alone or in a protein complex containing a kinase-dead CDC7 mutant and DBF4B. Coimmunoprecipitation studies showed that DBF4B and DBF4 binding to CDC7 was mutually exclusive, with no formation of ternary complexes.
Contacts	(Please send us your contacts, e.g.: email@google.com and your other information)
More advices
CheckCode