Editing Anti-Liver Cytosolic Antigen Type 1 Antibodies(Anti-LC1)

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Summary	<p>Antibodies to liver cytosol antigen type 1 (anti-LC1), which recognize a 60-kd peptide contained in the liver cytosolic fraction, have been reported to define a subset of autoimmune hepatitis (AIH) either negative for other autoantibodies or positive for anti-liver kidney microsomal antibody type 1 (LKM-1) and to be best detected in immunodiffusion. To analyze the prevalence of anti-LC1 in childhood liver disease, we have tested the sera of 95 patients using immunoblot, indirect immunofluorescence, and immunodiffusion. Fifteen children had smooth muscle antibody (SMA) and/or anti-nuclear antibody (ANA)-positive AIH, 13 had anti-LKM-1-positive AIH, 14 had autoimmune sclerosing cholangitis (ASC) (all SMA and/or ANA positive), and 53 had non-autoimmune liver disease (10 had α1-anti-trypsin deficiency [α1-ATD], 11 had Wilson&#39;s disease [WD], 14 had Alagille&#39;s syndrome, and 18 had chronic hepatitis B virus [HBV] infection).&nbsp;</p>
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