Cloud-Clone Clinical Diagnostic Reagents and Raw Materials #Cytokeratin 17 Antibody Reagent

Cytokeratin 17 (CK 17)  is a type I Keratin with a relative molecular weight of 46,000, which plays an important role in the formation and maintenance of various skin appendages. CK17 is mainly distributed in the basal cells of sweat glands and deep outer hair root sheath, and is mildly expressed in normal basal cells. Abnormal expression of CK17 occurs when epidermal keratinocytes show abnormal proliferation and differentiation. Several studies have shown that CK17 is abnormally expressed in a variety of skin diseases and cancers, including psoriasis, seborrheic keratosis, cutaneous squamous cell carcinoma, basal cell carcinoma, malignant melanoma, and other epithelial tumors. Therefore, CK17 is of great significance for the early diagnosis, curative effect monitoring and prognosis of these diseases.