Cloud-Clone products make contribution to the research of type II cardiorenal syndrome

Type II cardiorenal syndrome (CRSII) is one of the most severe cardiorenal syndrome. The renal impairment or renal insufficiency is caused by chronic cardiac insufficiency. And renal insufficiency also determines the prognosis of patients with Chronic heart failure (CHF) to a certain extent. At present, the acquaintance of CRSII is very limited. Due to its high incidence, poor prognosis, little knowledge about its pathogenesis and lack of effective measures, it is still a difficult problem for clinicians. Academician Hou FanFan and his team have made a breakthrough in the pathogenesis research of CRSII. And their research results "the Wnt/beta - catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome" famous periodicals published in 《kidney international》, a top journal in the field of  kidney disease. Based on the heart failure mice model of Aortic Arch Constriction, firstly the team proposed the molecular mechanism map of CRSII, providing an important reference for the prevention and treatment of CRSII.

Schematic diagram depicts cardiorenal inter-organ cross talk after TAC. Heart injury following TAC activates Wnt/ b -catenin and renin-angiotensin system (RAS) and leads to systemic inflammation with upregulation of TNF- a , IL-1 b , and monocyte chemoattractant protein (MCP)-1 in the circulation. Proinflammatory cytokines in the circulation subsequently suppresses renal klotho expression, which leads to the activation of Wnt/β -catenin and RAS in the kidney and causes podocyte and tubular injury and fibroblast activation. As the main source of systemic klotho, depressed renal production of klotho in the damaged kidney directly causes klotho deficiency in the circulation, which further aggravates Wnt-mediated cardiomyocyte hypertrophy and cardiac fibroblast activation after TAC, forming a vicious cycle. (Yue Zhao, etc. 2019)

In the research of academician HouFanfan and his team, the products from cloud-clone covered almost all the key targets. The most important cytokines, TNF-a, MCP-1 and IL1b, were from cloud-clone, SEA133Mi (ELISA Kit for Tumor Necrosis Factor Alpha (TNFa)), SEA087Mi (ELISA Kit for Monocyte chemoinvestigative Protein 1 (MCP1)), and SEA563Mu (ELISA Kit for Interleukin 1 Beta (IL1b)), respectively. Klotho, a key marker for kidney injury, and BNP, a key marker for heart injury, were also provided by cloud-clone, SEH757Mu (ELISA Kit for klotho (KL)) and SEA541Mu (ELISA Kit for Brain Natriuretic Peptide (BNP)), respectively. Cloud-Clone products with excellent quality have been favored by the academician team and made a small contribution to the research of CRSII.

For the targets in this article, more references are shown in following chart.