Cloud-Clone's SMD ELISA Kit has a good performance!

On February 18, 2020，professor Kodi S.Ravichandran from Center for Cell Clearance of University of Virginia co-authored with professor Ulrike Lorenz from Biomedical Molecular Biology of Ghent university published a paper named “Metabolites released from apoptotic cellsact as tissue messengers” on Nature. 

The ELISA kit (SMD, CEX053Ge) of Cloud-Clone brand was chosed to determine the concentation of SMD in this article, we are so proud for supporting the reaserchers.

The paper profiled the apoptotic metabolite secretome and determined its effects on the tissue neighbourhood. It shows that apoptotic lymphocytes and macrophages release specific metabolites, while retaining their membrane integrity. A subset of these metabolites is also shared across different primary cells and cell lines after the induction of apoptosis by different stimuli. Mechanistically, the apoptotic metabolite secretome is not simply due to passive emptying of cellular contents and instead is a regulated process. Caspase-mediated opening of pannexin 1 channels at the plasma membrane facilitated the release of a select subset of metabolites. In addition, certain metabolic pathways continued to remain active during apoptosis, with the release of only select metabolites from a given pathway. Functionally, the apoptotic metabolite secretome induced specific gene programs in healthy neighbouring cells, including suppression of inflammation, cell proliferation, and wound healing. Furthermore, a cocktail of apoptotic metabolites reduced disease severity in mouse models of inflammatory arthritis and lung-graft rejection. These data advance the concept that apoptotic cells are not inert cells waiting for removal, but instead release metabolites as 'good-bye' signals to actively modulate outcomes in tissues.