Top-Ranked ELISA Kits (Caspase-3 CASP3). Vol.3 (2019)

Caspase-3 (CASP3), also known as cysteine protease 3, is a protease that can specifically cut poly-ADP ribose polymerase (PARP1) and acetyl-DEVD-7-amino-4-methyl coumarin (Ac-DEVD-AMC), leading to DNA cleavage to promote cell apoptosis. CASP3 usually exists in the form of pro-caspase-3 in organisms. When apoptotic cells began to occur, pro-caspase-3 was cut from Asp28-Ser29 and Asp175-Ser176 to form two subunits, P17 (29-175) and P110 (182-277), which then formed the active form of CASP3. CASP3 as one of the most critical enzymes in apoptosis pathway, is closely related to the occurrence of cancer, aging and cardiovascular diseases.