Top-Ranked ELISA Kits (Osteocalcin OC). Vol.2 (2019)

Osteocalcin (OC), also known as R-hydroxy glutamic acid protein (GLa protein), is a protein consisting of 49 amino acids. It belongs to non-collagen acidic glycoprotein, which is a vitamin K-dependent calcium binding protein. Osteocalcin level is used to monitor bone development and bone metabolism, and its content is negatively correlated with age, as children being the highest and decreasing with age.

Osteocalcin is mainly synthesized of osteoblasts and odontoblasts, and some are synthesized by proliferating chondrocytes, which plays an important role in regulating bone calcium metabolism. It is a new biochemical marker for bone metabolism research, which is of great value in the diagnosis of osteoporosis syndrome, abnormal calcium metabolism and other diseases.