Top-Ranked ELISA Kits (Testosterone Testo). Vol.4 (2019)

Testosterone is a steroid hormone secreted by male testes or female ovaries. The adrenal gland also secretes a small amount of testosterone, which has two effects on humans and other vertebrates: directly or in the form of serum DHT to activate androgen receptors; and converted to estradiol to activate some estrogen receptors. Free testosterone is transported to the cytoplasm of target tissue cells, binds to androgen receptors, or is converted to serum DHT by 5a-reductase. DHT also binds to androgen receptors (which are more stable, and the male hormone intensity of DHT is about 2.5 times that of testosterone). Testosterone receptors or serum DHT receptors undergo structural changes that allow them to enter the nucleus and bind to specific nucleotides in chromosomal DNA. The binding region is called hormone response element (HRE), which affects the replication of certain genes and produces male hormone effects. Testosterone plays an important role in maintaining muscle strength and quality, maintaining bone density and strength, refreshing and improving physical fitness. It is an important indicator of reproductive development and growth of human body and vertebrates.