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Bone Morphogenetic Protein Receptor 2 (BMPR2)

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BMPRII; BMPR-II; BRK3; T-ALK; BMPR3; PPH1; Primary Pulmonary Hypertension 1; BMP type II receptor

Bone Morphogenetic Protein Receptor 2 (BMPR2)
CCC A016
HGNC 1078
MGI 1095407
PubMed 16429403
RGD 71082
UniProt Q13873
Wiki BMPR2

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands. BMPs are involved in host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which it phosphorylates. The Type I receptor phosphorylates an R-SMAD a transcriptional regulator.Unlike the TGFβ type II receptor, which has a high affinity for TGF-β1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor. In TGF beta signaling all of the receptors exist in homodimers before ligand binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA016Hu01 Recombinant Bone Morphogenetic Protein Receptor 2 (BMPR2) Positive Control; Immunogen; SDS-PAGE; WB.
APA016Hu01 Active Bone Morphogenetic Protein Receptor 2 (BMPR2) Cell culture; Activity Assays.
Antibodies PAA016Hu01 Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEA016Hu ELISA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Morphogenetic Protein Receptor 2 (BMPR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Morphogenetic Protein Receptor 2 (BMPR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) Polyclonal Antibody Customized Service Offer
Assay Kits SEA016Ra ELISA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Cloning and characterization of a human type II receptor for bone morphogenetic proteins."Proc. Natl. Acad. Sci. U.S.A. 92:7632-7636(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors."J. Biol. Chem. 270:22522-22526(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor."J. Biol. Chem. 270:5625-5630(1995) [PubMed] [Europe PMC] [Abstract]
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  9. "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the BMPR2 kinase domain."Submitted (FEB-2009) to the PDB data bank
  12. "Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene."Am. J. Hum. Genet. 67:737-744(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family." J. Med. Genet. 37:741-745(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension." Nat. Genet. 26:81-84(2000) [PubMed] [Europe PMC] [Abstract]
  15. "BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension." Am. J. Hum. Genet. 68:92-102(2001) [PubMed] [Europe PMC] [Abstract]
  16. "BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives."Eur. Respir. J. 20:518-523(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II."Am. J. Respir. Crit. Care Med. 167:889-894(2003) [PubMed] [Europe PMC] [Abstract]
  18. "BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension."Hum. Mutat. 26:119-124(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension." Hum. Mutat. 27:121-132(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations."PLoS ONE 9:E106703-E106703(2014) [PubMed] [Europe PMC] [Abstract]