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Factor Related Apoptosis (FAS)

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CD95; ALPS1A; ALPS1-A; APO1; APT1; FAS1; FASTM; TNFRSF6; Fas Receptor; TNF Receptor Superfamily Member 6; Tumor Necrosis Factor Receptor Superfamily Member 6

Factor Related Apoptosis (FAS)
CCC A030
HGNC 11920
MGI 95484
PubMed 16507928
RGD 619831
UniProt P25445
Wiki Fas_receptor

Fas  is a glycoprotein with a mass estimated at 43 to 48 kDa . Fas is a member of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), and it shares a cytoplasmic motif with TNF RI, referred to as the death domain, that binds cytoplasm signaling molecules to trigger the cytoplasmic apoptotic signal . Fas is expressed to a large extent on activated T and B lymphocytes, and on malignant lymphoid cells. To a lesser extent, Fas is expressed on cells from liver, heart, kidney, ovaries, and on many other malignant cells.
Yan et al. (2005) noted that the TNFRSF6 gene contains 9 exons. They identified an antisense transcript SAF within the 12.1-kb intron 1 that is transcribed in the opposite direction as the TNFRSF6 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA030Hu01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA030Hu02 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA030Hu03 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
APA030Hu01 Active Factor Related Apoptosis (FAS) Cell culture; Activity Assays.
APA030Hu03 Active Factor Related Apoptosis (FAS) Cell culture; Activity Assays.
EPA030Hu61 Eukaryotic Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
APA030Hu61 Active Factor Related Apoptosis (FAS) Cell culture; Activity Assays.
Antibodies PAA030Hu01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
MAA030Hu22 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAA030Hu02 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC
LAA030Hu71 Biotin-Linked Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC.
LAA030Hu81 FITC-Linked Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
PAA030Hu03 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
Assay Kits SEA030Hu ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA030Hu CLIA Kit for Factor Related Apoptosis (FAS) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA030Mu01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA030Mu02 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
EPA030Mu61 Eukaryotic Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA030Mu01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAA030Mu02 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
LAA030Mu71 Biotin-Linked Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC.
Assay Kits SEA030Mu ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA030Mu CLIA Kit for Factor Related Apoptosis (FAS) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA030Ra01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA030Ra02 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA030Ra03 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
EPA030Ra61 Eukaryotic Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
APA030Ra61 Active Factor Related Apoptosis (FAS) Cell culture; Activity Assays.
EPA030Ra62 Eukaryotic Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA030Ra01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAA030Ra02 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
LAA030Ra71 Biotin-Linked Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC.
LAA030Ra81 FITC-Linked Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
PAA030Ra03 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
MAA030Ra21 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAA030Ra06 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
Assay Kits SEA030Ra ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA030Si01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA030Si01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Factor Related Apoptosis (FAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Factor Related Apoptosis (FAS) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA030Po01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA030Po01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Factor Related Apoptosis (FAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Factor Related Apoptosis (FAS) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA030Bo01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA030Bo02 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA030Bo01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Factor Related Apoptosis (FAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Factor Related Apoptosis (FAS) ELISA Kit Customized Service Offer
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  2. "Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen."J. Biol. Chem. 267:10709-10715(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation."Biochem. J. 310:957-963(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing."J. Immunol. 154:2706-2713(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis."J. Immunol. 156:13-17(1996) [PubMed] [Europe PMC] [Abstract]
  6. "An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro."J. Immunol. 156:4622-4630(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation."Immunobiology 212:73-83(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death."Cell 81:513-523(1995) [PubMed] [Europe PMC] [Abstract]
  12. "F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis."J. Biol. Chem. 274:32461-32468(1999) [PubMed] [Europe PMC] [Abstract]
  13. "LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death."Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999) [PubMed] [Europe PMC] [Abstract]
  14. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
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  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain."Nature 384:638-641(1996) [PubMed] [Europe PMC] [Abstract]
  25. "The Fas-FADD death domain complex structure unravels signalling by receptor clustering."Nature 457:1019-1022(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome."Cell 81:935-946(1995) [PubMed] [Europe PMC] [Abstract]
  27. "Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity."N. Engl. J. Med. 335:1643-1649(1996) [PubMed] [Europe PMC] [Abstract]
  28. "Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis."Blood 89:902-909(1997) [PubMed] [Europe PMC] [Abstract]
  29. "Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis."Blood 89:1341-1348(1997) [PubMed] [Europe PMC] [Abstract]
  30. "Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis."Gastroenterology 113:1384-1389(1997) [PubMed] [Europe PMC] [Abstract]
  31. "Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity."Blood 92:3018-3024(1998) [PubMed] [Europe PMC] [Abstract]
  32. "The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis."J. Pediatr. 133:629-633(1998) [PubMed] [Europe PMC] [Abstract]
  33. "Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance."Am. J. Hum. Genet. 64:1002-1014(1999) [PubMed] [Europe PMC] [Abstract]
  34. "Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations."Blood 94:2575-2582(1999) [PubMed] [Europe PMC] [Abstract]
  35. "Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease."Exp. Hematol. 27:868-874(1999) [PubMed] [Europe PMC] [Abstract]
  36. "The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations."J. Clin. Invest. 103:355-363(1999) [PubMed] [Europe PMC] [Abstract]
  37. "Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar."J. Invest. Dermatol. 114:122-126(2000) [PubMed] [Europe PMC] [Abstract]
  38. "The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis."Blood 98:194-200(2001) [PubMed] [Europe PMC] [Abstract]
  39. "The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations."Nat. Struct. Mol. Biol. 17:1324-1329(2010) [PubMed] [Europe PMC] [Abstract]