≡

Fibroblast Growth Factor 4 (FGF4)

[Edit]

HBGF4; HST; HSTF1; KFGF; K-FGF; Heparin Secretory Transforming Protein 1; Kaposi Sarcoma Oncogene; Transforming Protein KS3; FGF-Related Oncogene

Fibroblast Growth Factor 4 (FGF4)
CCC A034
HGNC 3682
MGI 95518
PubMed 9851926
RGD 620127
UniProt P08620
Wiki FGF4

Fibroblast growth factor 4 is a protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity.

This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA034Hu01 Recombinant Fibroblast Growth Factor 4 (FGF4) Positive Control; Immunogen; SDS-PAGE; WB.
APA034Hu01 Active Fibroblast Growth Factor 4 (FGF4) Cell culture; Activity Assays.
Antibodies PAA034Hu01 Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
MAA034Hu22 Monoclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
Assay Kits SEA034Hu ELISA Kit for Fibroblast Growth Factor 4 (FGF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA034Hu CLIA Kit for Fibroblast Growth Factor 4 (FGF4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA034Mu01 Recombinant Fibroblast Growth Factor 4 (FGF4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA034Mu02 Recombinant Fibroblast Growth Factor 4 (FGF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA034Mu01 Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
PAA034Mu02 Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
Assay Kits SEA034Mu ELISA Kit for Fibroblast Growth Factor 4 (FGF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA034Mu CLIA Kit for Fibroblast Growth Factor 4 (FGF4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA034Ra01 Recombinant Fibroblast Growth Factor 4 (FGF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA034Ra01 Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
MAA034Ra21 Monoclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
Assay Kits SEA034Ra ELISA Kit for Fibroblast Growth Factor 4 (FGF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA034Ra CLIA Kit for Fibroblast Growth Factor 4 (FGF4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA034Bo01 Recombinant Fibroblast Growth Factor 4 (FGF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA034Bo01 Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
MAA034Bo21 Monoclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
Assay Kits SEA034Bo ELISA Kit for Fibroblast Growth Factor 4 (FGF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA034Bo CLIA Kit for Fibroblast Growth Factor 4 (FGF4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor 4 (FGF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor 4 (FGF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor 4 (FGF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor 4 (FGF4) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA034Ga01 Recombinant Fibroblast Growth Factor 4 (FGF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA034Ga01 Polyclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
MAA034Ga21 Monoclonal Antibody to Fibroblast Growth Factor 4 (FGF4) WB; IHC; ICC; IP.
Assay Kits SEA034Ga ELISA Kit for Fibroblast Growth Factor 4 (FGF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA034Ga CLIA Kit for Fibroblast Growth Factor 4 (FGF4) Chemiluminescent immunoassay for Antigen Detection.
  1. "Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal."Stem Cells 26:767-774(2008) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein."Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity."Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987) [PubMed] [Europe PMC] [Abstract]
  4. "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family."Cell 50:729-737(1987) [PubMed] [Europe PMC] [Abstract]
  5. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis."Mol. Cell. Biol. 21:5946-5957(2001) [PubMed] [Europe PMC] [Abstract]