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FMS Like Tyrosine Kinase 3 (Flt3)

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CD135; STK1; FLK2; Fms-Related Tyrosine Kinase 3; Stem Cell Tyrosine Kinase 1; FL Cytokine Receptor; Fetal Liver Kinase-2

FMS Like Tyrosine Kinase 3 (Flt3)
CCC A039
HGNC 3765
MGI 95559
PubMed 22797419
RGD 61308
UniProt P36888
Wiki CD135

CD135 is a cytokine receptor expressed on the surface of hematopoietic progenitor cells.Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of antibodies, used to identify the cell type, stage of differentiation and activity of a cell.

CD135 is an important cell surface marker used to identify certain types of hematopoietic (blood) progenitors in the bone marrow. Specifically, multipotent progenitors (MPP) and common lymphoid progenitors (CLP) expresse high surface levels of CD135. This marker is therefore used to differentiate hematopoietic stem cells (HSC), which are CD135 negative, from MPPs, which are CD135 positive.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA039Hu01 Recombinant FMS Like Tyrosine Kinase 3 (Flt3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA039Hu01 Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) WB; IHC; ICC; IP.
MAA039Hu22 Monoclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) WB; IHC; ICC; IP.
Assay Kits SEA039Hu ELISA Kit for FMS Like Tyrosine Kinase 3 (Flt3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA039Mu01 Recombinant FMS Like Tyrosine Kinase 3 (Flt3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA039Mu01 Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) WB; IHC; ICC; IP.
LAA039Mu71 Biotin-Linked Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for FMS Like Tyrosine Kinase 3 (Flt3) CLIA Kit Customized Service Offer
n/a ELISA Kit for FMS Like Tyrosine Kinase 3 (Flt3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FMS Like Tyrosine Kinase 3 (Flt3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FMS Like Tyrosine Kinase 3 (Flt3) CLIA Kit Customized Service Offer
n/a ELISA Kit for FMS Like Tyrosine Kinase 3 (Flt3) ELISA Kit Customized Service Offer
  1. "STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells."Proc. Natl. Acad. Sci. U.S.A. 91:459-463(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells."Blood 82:1110-1119(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene."Genomics 9:380-385(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells."Leukemia 10:238-248(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Internal tandem duplication of the flt3 gene found in acute myeloid leukemia."Leukemia 10:1911-1918(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product."Leukemia 12:1333-1337(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells."J. Leukoc. Biol. 65:372-380(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways."Blood 96:3907-3914(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation."Cancer Res. 65:9643-9650(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases."Mol. Cell. Biol. 25:3690-3703(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD."Blood 108:1339-1345(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2."Blood 108:1542-1550(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Structural and numerical variation of FLT3/ITD in pediatric AML."Blood 111:4930-4933(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival."J. Immunol. 180:7358-7367(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation."Exp. Hematol. 37:979-989(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  19. "FES kinases are required for oncogenic FLT3 signaling."Leukemia 24:721-728(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation."Leukemia 24:1412-1421(2010) [PubMed] [Europe PMC] [Abstract]
  21. "mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells."Mol. Cancer 9:292-292(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."J. Biol. Chem. 286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Further activation of FLT3 mutants by FLT3 ligand."Oncogene 30:4004-4014(2011) [PubMed] [Europe PMC] [Abstract]
  24. "The role of FLT3 in haematopoietic malignancies."Nat. Rev. Cancer 3:650-665(2003) [PubMed] [Europe PMC] [Abstract]
  25. "Structural and functional alterations of FLT3 in acute myeloid leukemia."Clin. Cancer Res. 15:4263-4269(2009) [PubMed] [Europe PMC] [Abstract]
  26. "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain."Mol. Cell 13:169-178(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex."Blood 118:60-68(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia."Br. J. Haematol. 113:983-988(2001) [PubMed] [Europe PMC] [Abstract]
  29. "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies."Blood 97:2434-2439(2001) [PubMed] [Europe PMC] [Abstract]
  30. "FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy."Blood 103:1085-1088(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  32. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]