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Growth Hormone (GH)

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GH1; GH-N; GHN; hGH-N; Somatotropin; Hygetropin; Jintropin; Kigtropin; Pituitary Growth Hormone; Growth Hormone, Normal

Growth Hormone (GH)
CCC A044
HGNC 4261
MGI 95707
PubMed 18090659
RGD 2686
UniProt P01241
Wiki GH

Somatotropin is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity.

Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Hu01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
EPA044Hu61 Eukaryotic Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
APA044Hu01 Active Growth Hormone (GH) Cell culture; Activity Assays.
Antibodies PAA044Hu01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Hu22 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAA044Hu06 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
LAA044Hu72 Biotin-Linked Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC.
MAA044Hu26 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Hu21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Hu23 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Hu24 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Hu25 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Hu ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA044Hu ELISA Kit for Anti-Growth Hormone Antibody (Anti-GH) Enzyme-linked immunosorbent assay for Antibody Detection.
SCA044Hu CLIA Kit for Growth Hormone (GH) Chemiluminescent immunoassay for Antigen Detection.
CEA044Hu ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Mu01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
RPA044Mu02 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
APA044Mu01 Active Growth Hormone (GH) Cell culture; Activity Assays.
EPA044Mu61 Eukaryotic Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
APA044Mu61 Active Growth Hormone (GH) Cell culture; Activity Assays.
Antibodies PAA044Mu01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAA044Mu02 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Mu ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA044Mu CLIA Kit for Growth Hormone (GH) Chemiluminescent immunoassay for Antigen Detection.
CEA044Mu ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Ra01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA044Ra01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Ra21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Ra ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA044Ra CLIA Kit for Growth Hormone (GH) Chemiluminescent immunoassay for Antigen Detection.
CEA044Ra ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
CCA044Ra CLIA Kit for Growth Hormone (GH) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Hormone (GH) Recombinant Protein Customized Service Offer
Antibodies PAA044Gu01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Growth Hormone (GH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Hormone (GH) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Ca01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
EPA044Ca61 Eukaryotic Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
APA044Ca61 Active Growth Hormone (GH) Cell culture; Activity Assays.
Antibodies PAA044Ca01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Ca21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Ca ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA044Ca ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Po01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
CPA044Po21 OVA Conjugated Growth Hormone (GH) Immunogen; SDS-PAGE; WB.
EPA044Po61 Eukaryotic Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
EPA044Po62 Eukaryotic Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
APA044Po61 Active Growth Hormone (GH) Cell culture; Activity Assays.
APA044Po62 Active Growth Hormone (GH) Cell culture; Activity Assays.
Antibodies PAA044Po01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Po21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAA044Po08 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Po ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA044Po ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Bo01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
EPA044Bo61 Eukaryotic Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
APA044Bo61 Active Growth Hormone (GH) Cell culture; Activity Assays.
Antibodies PAA044Bo01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Bo21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Bo ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA044Bo ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Hormone (GH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Hormone (GH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Hormone (GH) Polyclonal Antibody Customized Service Offer
Assay Kits CEA044Ov ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Eq01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA044Eq01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Eq21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits CEA044Eq ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA044Ga01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA044Ga01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
MAA044Ga21 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
Assay Kits SEA044Ga ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA044Ga CLIA Kit for Growth Hormone (GH) Chemiluminescent immunoassay for Antigen Detection.
CEA044Ga ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Human growth hormone: complementary DNA cloning and expression in bacteria."Science 205:602-607(1979) [PubMed] [Europe PMC] [Abstract]
  3. "Human growth hormone DNA sequence and mRNA structure: possible alternative splicing."Nucleic Acids Res. 9:3719-3730(1981) [PubMed] [Europe PMC] [Abstract]
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  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Periplasmic production of correctly processed human growth hormone in Escherichia coli: natural and bacterial signal sequences are interchangeable."Gene 39:247-254(1985) [PubMed] [Europe PMC] [Abstract]
  11. "Human pituitary growth hormone. XIX. The primary structure of the hormone."Arch. Biochem. Biophys. 133:70-91(1969) [PubMed] [Europe PMC] [Abstract]
  12. "Human pituitary growth hormone. 32. The primary structure of the hormone: revision."Arch. Biochem. Biophys. 146:233-236(1971) [PubMed] [Europe PMC] [Abstract]
  13. "Sequence comparison of human pituitary growth hormone, human chorionic somatomammotropin, and ovine pituitary growth and lactogenic hormones."Int. J. Pept. Protein Res. 4:281-287(1972) [PubMed] [Europe PMC] [Abstract]
  14. "Revised primary structure for human growth hormone."Nature New Biol. 230:90-91(1971) [PubMed] [Europe PMC] [Abstract]
  15. "Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication."Proc. Natl. Acad. Sci. U.S.A. 68:866-869(1971) [PubMed] [Europe PMC] [Abstract]
  16. "The chemistry of the human lactogenic hormones."(In) Griffiths K. (eds.);Prolactin and carcinogenesis, Proc. fourth tenovus workshop prolactin, pp.13-20, Alpha Omega Alpha Press, Cardiff (1972)
  17. "The 20,000 molecular weight variant of human growth hormone. Preparation and some physical and chemical properties."J. Biol. Chem. 256:2395-2401(1981) [PubMed] [Europe PMC] [Abstract]
  18. "The 20,000-dalton variant of human growth hormone: location of the amino acid deletions."Biochem. Biophys. Res. Commun. 92:511-516(1980) [PubMed] [Europe PMC] [Abstract]
  19. "Altered proteolytic cleavage of human growth hormone as a result of deamidation."J. Biol. Chem. 256:11645-11650(1981) [PubMed] [Europe PMC] [Abstract]
  20. "A new mutation causing inherited growth hormone deficiency: a compound heterozygote of a 6.7 kb deletion and a two base deletion in the third exon of the GH-1 gene."Hum. Mol. Genet. 2:1073-1074(1993) [PubMed] [Europe PMC] [Abstract]
  21. "Identification and characterization of phosphorylated proteins in the human pituitary."Proteomics 4:587-598(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Growth hormone heterogeneity in human pituitary and plasma."Horm. Res. 51 Suppl. 1:2-6(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Phosphoproteomic analysis of the human pituitary."Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Prediction of the three-dimensional structure of human growth hormone."Proteins 2:162-166(1987) [PubMed] [Europe PMC] [Abstract]
  25. "Human growth hormone and extracellular domain of its receptor: crystal structure of the complex."Science 255:306-312(1992) [PubMed] [Europe PMC] [Abstract]
  26. "The X-ray structure of a growth hormone-prolactin receptor complex."Nature 372:478-481(1994) [PubMed] [Europe PMC] [Abstract]
  27. "The crystal-structure of wild-type growth-hormone at 2.5-A resolution."Protein Pept. Lett. 2:333-340(1995)
  28. "Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9-A resolution."J. Biol. Chem. 271:32197-32203(1996) [PubMed] [Europe PMC] [Abstract]
  29. "Short stature caused by a mutant growth hormone."N. Engl. J. Med. 334:432-436(1996) [PubMed] [Europe PMC] [Abstract]
  30. ErratumN. Engl. J. Med. 334:1207-1207(1996)
  31. "Detection of growth hormone gene defects by dideoxy fingerprinting (ddF)."Endocr. J. 44:149-154(1997) [PubMed] [Europe PMC] [Abstract]
  32. "Biologically inactive growth hormone caused by an amino acid substitution."J. Clin. Invest. 100:1159-1165(1997) [PubMed] [Europe PMC] [Abstract]
  33. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  34. ErratumNat. Genet. 23:373-373(1999)
  35. "Autosomal dominant GH deficiency due to an Arg183His GH-1 gene mutation: clinical and molecular evidence of impaired regulated GH secretion."J. Clin. Endocrinol. Metab. 86:3941-3947(2001) [PubMed] [Europe PMC] [Abstract]
  36. "Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature."Hum. Mutat. 21:424-440(2003) [PubMed] [Europe PMC] [Abstract]
  37. "A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathway."J. Clin. Endocrinol. Metab. 89:1068-1075(2004) [PubMed] [Europe PMC] [Abstract]
  38. "Short stature caused by a biologically inactive mutant growth hormone (GH-C53S)."J. Clin. Endocrinol. Metab. 90:2493-2499(2005) [PubMed] [Europe PMC] [Abstract]
  39. "Evaluation of the biological activity of a growth hormone (GH) mutant (R77C) and its impact on GH responsiveness and stature."J. Clin. Endocrinol. Metab. 92:2893-2901(2007) [PubMed] [Europe PMC] [Abstract]