≡

Glycoprotein 130 (gp130)

[Edit]

CDw130; CD130; IL6ST; GP130-RAPS; IR6RB; IL6R-Beta; IR6RB; IR6-RB; Interleukin 6 Signal Transducer; Oncostatin M Receptor; Interleukin-6 Receptor Subunit Beta

Glycoprotein 130 (gp130)
CCC A046
HGNC 6021
MGI 96560
PubMed 11251120
RGD 2903
UniProt P40189
Wiki GP130

Glycoprotein 130 is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement.

As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA046Hu01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
RPA046Hu02 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
EPA046Hu61 Eukaryotic Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
APA046Hu61 Active Glycoprotein 130 (gp130) Cell culture; Activity Assays.
Antibodies PAA046Hu01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
MAA046Hu22 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAA046Hu02 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
LAA046Hu71 Biotin-Linked Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC.
Assay Kits SEA046Hu ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA046Mu01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
RPA046Mu02 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA046Mu01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAA046Mu02 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
Assay Kits SEA046Mu ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA046Ra01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA046Ra01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
MAA046Ra21 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
Assay Kits SEA046Ra ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and expression of an IL-6 signal transducer, gp130."Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis."J. Clin. Invest. 106:137-144(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130."J. Biol. Chem. 276:8244-8253(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines."Exp. Hematol. 25:1367-1377(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling."J. Biol. Chem. 275:22574-22582(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling."J. Virol. 75:3325-3334(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of a cytokine-binding region of gp130."EMBO J. 17:1665-1674(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of an extracellular gp130 cytokine receptor signaling complex."Science 291:2150-2155(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."Mol. Cell 12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."Science 300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]
  21. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]