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Insulin Like Growth Factor Binding Protein 3 (IGFBP3)

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BP53; IBP3; Growth Hormone-Dependent Binding Protein; Acid Stable Subunit Of The 140 K IGF Complex

Insulin Like Growth Factor Binding Protein 3 (IGFBP3)
CCC A054
HGNC 5472
MGI 96438
PubMed 18084616
RGD 2874
UniProt P17936
Wiki IGFBP3

The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

IGFBP3 protein levels decrease during the progression of prostate cancer from benign prostatic hyperplasia (BPH) to its metastatic form.Although, production of the protein does not cease completely. IGFBP3 is still made (at a lower level) by prostate cancer cells and secreted into the surrounding environment. However, instead of the full length, functional protein, IGFBP3 is found to be cleaved.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Hu01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
APA054Hu01 Active Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Cell culture; Activity Assays.
RPA054Hu02 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
EPA054Hu61 Eukaryotic Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA054Hu03 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
APA054Hu02 Active Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Cell culture; Activity Assays.
EPA054Hu62 Eukaryotic Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Hu22 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
LAA054Hu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC.
MAA054Hu21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Hu23 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Hu24 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB
MAA054Hu25 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Hu27 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Hu29 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits SEA054Hu ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Mu01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA054Mu02 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
APA054Mu61 Active Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Cell culture; Activity Assays.
EPA054Mu61 Eukaryotic Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Mu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
LAA054Mu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC.
PAA054Mu02 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits SEA054Mu ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Ra01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Ra01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
LAA054Ra71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC.
LAA054Ra81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IF.
MAA054Ra21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits SEA054Ra ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Po01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Po01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Po21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits SEA054Po ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Bo01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Bo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
MAA054Bo21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits SEA054Bo ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Cp01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Cp01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Eq01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Eq01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Ga01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Ga01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA054Fi01 Recombinant Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA054Fi01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 3 (IGFBP3) ELISA Kit Customized Service Offer
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  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis."Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer."J. Biol. Chem. 285:30233-30246(2010) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]