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Insulin Like Growth Factor Binding Protein 4 (IGFBP4)

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BP4; HT29-IGFBP; IBP4

Insulin Like Growth Factor Binding Protein 4 (IGFBP4)
CCC A055
HGNC 5473
MGI 96439
PubMed 21207373
RGD 2875
UniProt P22692
Wiki IGFBP4

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.The protein itself does not prevent the formation of cancer.However it may reduce the growth of cancer and act as an apoptotic factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Hu01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA055Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
MAA055Hu22 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB
LAA055Hu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC.
LAA055Hu81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IF.
MAA055Hu24 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB
MAA055Hu26 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB
LAA055Hu76 Biotin-Linked Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC.
MAA055Hu21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
MAA055Hu23 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
MAA055Hu25 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
MAA055Hu27 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits SEA055Hu ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA055Hu CLIA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Mu01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA055Mu02 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA055Mu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
PAA055Mu02 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits SEA055Mu ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Ra01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies LAA055Ra71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC.
LAA055Ra81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IF.
PAA055Ra01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits SEA055Ra ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Po01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA055Po01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits SEA055Po ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Bo01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA055Bo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
MAA055Bo21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits CEA055Bo ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Cp01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA055Cp01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA055Ga01 Recombinant Insulin Like Growth Factor Binding Protein 4 (IGFBP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA055Ga01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 4 (IGFBP4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 4 (IGFBP4) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human."Mol. Endocrinol. 4:1451-1458(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation."Mol. Endocrinol. 4:1806-1814(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum."J. Biol. Chem. 266:9043-9049(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Structural and functional analysis of the 5'-flanking region of the human insulin-like growth factor binding protein (IGFBP)-4 gene."Biochim. Biophys. Acta 1350:136-140(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4)."Genomics 49:401-410(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein."Cancer Res. 51:2813-2819(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system."Growth Regul. 1:110-118(1991) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for the regulation of insulin-like growth factors by IGF binding proteins."Structure 13:155-167(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]