Interleukin 12A (IL12A)
[Edit]p35; IL12-A; CLMF1; NFSK; NKSF1; Natural Killer Cell Stimulatory Factor 1; Cytotoxic Lymphocyte Maturation Factor 1; NF Cell Stimulatory Factor Chain 1
Interleukin 12A also known as IL12A encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family.
This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Mu01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA059Mu02 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAA059Mu01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
PAA059Mu02 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
LAA059Mu71 | Biotin-Linked Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC. | |
Assay Kits | SEA059Mu | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Ra01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Ra01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Ra21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Ra | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Ca01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Ca01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Ca21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Ca | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Po01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Po01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Po21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Po | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Bo01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Bo01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Bo21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Bo | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Capra hircus; Caprine (Goat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Cp01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Cp01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Cp21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Cp | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Eq01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Eq01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Eq21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Eq | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA059Ga01 | Recombinant Interleukin 12A (IL12A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA059Ga01 | Polyclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. |
MAA059Ga21 | Monoclonal Antibody to Interleukin 12A (IL12A) | WB; IHC; ICC; IP. | |
Assay Kits | SEA059Ga | ELISA Kit for Interleukin 12A (IL12A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells."J. Immunol. 146:3074-3081(1991) [PubMed] [Europe PMC] [Abstract]
- "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor."Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147(1991) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells."Proc. Natl. Acad. Sci. U.S.A. 87:6808-6812(1990) [PubMed] [Europe PMC] [Abstract]
- "Sequence similarity between NKSF and the IL-6/G-CSF family."Immunol. Today 13:77-78(1992) [PubMed] [Europe PMC] [Abstract]
- "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
- "Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12."EMBO J. 19:3530-3541(2000) [PubMed] [Europe PMC] [Abstract]