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Prokineticin Receptor 2 (PKR2)

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PROKR2; KAL3; GPR73L1; GPR73b; GPRg2; G Protein-Coupled receptor 73-Like 1

Prokineticin Receptor 2 (PKR2)
CCC A075
HGNC 15836
MGI 2181363
PubMed 17202262
RGD 708445
UniProt Q8NFJ6
Wiki PKR2
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.
Lin et al. (2002) cloned human GPR73L1 (PROKR2) by PCR of a pooled testis and fetal brain cDNA library. They also cloned GPR73 (PROKR1), which shares 85% overall sequence identity with GPR73L1. The greatest divergence between the proteins is in the N terminus, and both share about 80% sequence identity with mouse Gpr73. RT-PCR detected expression of GPR73L1 in brain, testis, small intestine, ovary, thyroid, pituitary, and salivary gland.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA075Hu01 Recombinant Prokineticin Receptor 2 (PKR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA075Hu01 Polyclonal Antibody to Prokineticin Receptor 2 (PKR2) WB; IHC; ICC; IP.
MAA075Hu22 Monoclonal Antibody to Prokineticin Receptor 2 (PKR2) WB; IHC; ICC; IP.
Assay Kits SEA075Hu ELISA Kit for Prokineticin Receptor 2 (PKR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prokineticin Receptor 2 (PKR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prokineticin Receptor 2 (PKR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prokineticin Receptor 2 (PKR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prokineticin Receptor 2 (PKR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prokineticin Receptor 2 (PKR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prokineticin Receptor 2 (PKR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prokineticin Receptor 2 (PKR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prokineticin Receptor 2 (PKR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prokineticin Receptor 2 (PKR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prokineticin Receptor 2 (PKR2) ELISA Kit Customized Service Offer
  1. "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of prokineticin receptors."Biochim. Biophys. Acta 1579:173-179(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Evidence that prokineticin receptor 2 exists as a dimer in vivo."Cell. Mol. Life Sci. 68:2919-2929(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2."PLoS Genet. 2:1648-1652(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum."J. Clin. Endocrinol. Metab. 93:3551-3559(2008) [PubMed] [Europe PMC] [Abstract]
  8. "PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity."Hum. Mol. Genet. 18:75-81(2009) [PubMed] [Europe PMC] [Abstract]
  9. "SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome." PLoS Genet. 8:E1002896-E1002896(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
  11. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]