Interleukin 8 (IL8)
[Edit]CXCL8; AMCF-I; GCP1; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP1; SCYB8; TSG1; B-ENAP; Neutrophil-Activating Protein 1; Granulocyte Chemotactic Protein 1
CCC | A080 |
HGNC | 6025 |
PubMed | 7964163 |
UniProt | P10145 |
Wiki | Interleukin_8 |
Interleukin 8 (IL-8), a member of the neutrophil-specific CXC subfamily of chemokines, is a potent neutrophil chemotactic and activating factor. It is a primary inflammatory cytokine produced by many cells in response to proinflammatory stimuli such as IL-1, TNF, LPS and viruses. Its function is, in part, to attract neutrophils to the site of inflammation and to activate them. The IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa). Further proteolysis of the N-terminal end leads to a variant form with 72 amino acids; full activation of IL-8 may require cleavage to the 72 amino acid form. IL-8 can form non-covalent dimers in solution, especially at high concentrations, but dimerization is not necessary for biological activity.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Hu01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA080Hu01 | Active Interleukin 8 (IL8) | Cell culture; Activity Assays. | |
Antibodies | PAA080Hu01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
MAA080Hu22 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Hu82 | FITC-Linked Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
LAA080Hu72 | Biotin-Linked Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Hu71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Hu81 | FITC-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
MAA080Hu24 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Hu21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Hu23 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Hu | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCA080Hu | CLIA Kit for Interleukin 8 (IL8) | Chemiluminescent immunoassay for Antigen Detection. | |
HEA080Hu | High Sensitive ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
IEA080Hu | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
AEA080Hu | ELISA Kit for Anti-Interleukin 8 Antibody (Anti-IL8) | Enzyme-linked immunosorbent assay for Antibody Detection. |
Organism species: Cavia (Guinea pig )
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Gu01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA080Gu01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
LAA080Gu71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Gu81 | FITC-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
MAA080Gu21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Gu24 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Gu | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Gu | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Rb01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA080Rb02 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APA080Rb01 | Active Interleukin 8 (IL8) | Cell culture; Activity Assays. | |
Antibodies | PAA080Rb52 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
PAA080Rb51 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Rb22 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Rb71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Rb72 | Biotin-Linked Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Rb42 | PE-Linked Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
MAA080Rb21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Rb23 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Rb | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Rb | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Si01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA080Si01 | Active Interleukin 8 (IL8) | Cell culture; Activity Assays. | |
Antibodies | PAA080Si01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
MAA080Si22 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Si71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
MAA080Si21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Si | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Si | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Ca01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA080Ca01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC |
MAA080Ca22 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Ca71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Ca81 | FITC-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
MAA080Ca21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Ca | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCA080Ca | CLIA Kit for Interleukin 8 (IL8) | Chemiluminescent immunoassay for Antigen Detection. | |
IEA080Ca | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Po01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA080Po01 | Active Interleukin 8 (IL8) | Cell culture; Activity Assays. | |
Antibodies | PAA080Po01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
MAA080Po22 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Po71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Po81 | FITC-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
MAA080Po24 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Po26 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Po76 | Biotin-Linked Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
Assay Kits | SEA080Po | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCA080Po | CLIA Kit for Interleukin 8 (IL8) | Chemiluminescent immunoassay for Antigen Detection. | |
IEA080Po | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Bo01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
EPA080Bo61 | Eukaryotic Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APA080Bo61 | Active Interleukin 8 (IL8) | Cell culture; Activity Assays. | |
Antibodies | PAA080Bo01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
MAA080Bo21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Bo | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Bo | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Capra hircus; Caprine (Goat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Cp01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA080Cp01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Interleukin 8 (IL8) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Interleukin 8 (IL8) | ELISA Kit Customized Service Offer |
Organism species: Ovis aries; Ovine (Sheep)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Ov01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA080Ov01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
LAA080Ov71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
Assay Kits | SEA080Ov | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Ov | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Eq01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA080Eq01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
LAA080Eq71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
MAA080Eq21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Eq | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Eq | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA080Ga01 | Recombinant Interleukin 8 (IL8) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA080Ga01 | Active Interleukin 8 (IL8) | Cell culture; Activity Assays. | |
Antibodies | PAA080Ga01 | Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. |
MAA080Ga22 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
LAA080Ga71 | Biotin-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC. | |
LAA080Ga81 | FITC-Linked Polyclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IF. | |
MAA080Ga21 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
MAA080Ga23 | Monoclonal Antibody to Interleukin 8 (IL8) | WB; IHC; ICC; IP. | |
Assay Kits | SEA080Ga | ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEA080Ga | Instant ELISA Kit for Interleukin 8 (IL8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes."J. Immunol. 139:250-256(1987) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor."J. Exp. Med. 167:1883-1893(1988) [PubMed] [Europe PMC] [Abstract]
- "Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8."J. Immunol. 143:1366-1371(1989) [PubMed] [Europe PMC] [Abstract]
- "Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes."Mol. Cell. Biol. 9:1946-1957(1989) [PubMed] [Europe PMC] [Abstract]
- "Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes."Immunol. Lett. 24:165-169(1990) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of beta-thromboglobulin."Eur. J. Biochem. 181:337-344(1989) [PubMed] [Europe PMC] [Abstract]
- "The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms."Eur. J. Immunol. 20:2113-2118(1990) [PubMed] [Europe PMC] [Abstract]
- "Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence."Mol. Immunol. 26:87-93(1989) [PubMed] [Europe PMC] [Abstract]
- "Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells."J. Exp. Med. 169:1895-1901(1989) [PubMed] [Europe PMC] [Abstract]
- "Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale."Adv. Exp. Med. Biol. 305:97-107(1991) [PubMed] [Europe PMC] [Abstract]
- "Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts."Biochem. J. 259:585-588(1989) [PubMed] [Europe PMC] [Abstract]
- "Isolation and amino acid sequence of a chemotactic protein, LECT/interleukin 8, from a human myeloid leukemia cell line, ML-1."Immunol. Lett. 36:71-81(1993) [PubMed] [Europe PMC] [Abstract]
- "Structure determination of a human lymphocyte derived neutrophil activating peptide (LYNAP)."Biochem. Biophys. Res. Commun. 151:883-890(1988) [PubMed] [Europe PMC] [Abstract]
- "Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines."Proc. Natl. Acad. Sci. U.S.A. 84:9233-9237(1987) [PubMed] [Europe PMC] [Abstract]
- "Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes."Biochem. Biophys. Res. Commun. 149:755-761(1987) [PubMed] [Europe PMC] [Abstract]
- "Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils."J. Immunol. 145:3033-3040(1990) [PubMed] [Europe PMC] [Abstract]
- "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide."Biochemistry 30:3128-3135(1991) [PubMed] [Europe PMC] [Abstract]
- "Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact."Blood 96:2673-2681(2000) [PubMed] [Europe PMC] [Abstract]
- "Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma."J. Biol. Chem. 277:24584-24593(2002) [PubMed] [Europe PMC] [Abstract]
- "Interleukin-8, a chemotactic and inflammatory cytokine."FEBS Lett. 307:97-101(1992) [PubMed] [Europe PMC] [Abstract]
- "Regulation of the immune response by the interaction of chemokines and proteases."Adv. Immunol. 81:1-44(2003) [PubMed] [Europe PMC] [Abstract]
- "Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation."J. Exp. Med. 205:2085-2097(2008) [PubMed] [Europe PMC] [Abstract]
- "Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation."Haematologica 94:1346-1353(2009) [PubMed] [Europe PMC] [Abstract]
- "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."J. Biol. Chem. 285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]
- "Determination of the secondary structure of interleukin-8 by nuclear magnetic resonance spectroscopy."J. Biol. Chem. 264:18907-18911(1989) [PubMed] [Europe PMC] [Abstract]
- "Three-dimensional structure of interleukin 8 in solution."Biochemistry 29:1689-1696(1990) [PubMed] [Europe PMC] [Abstract]
- "Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein."Eur. J. Biochem. 235:26-35(1996) [PubMed] [Europe PMC] [Abstract]
- "Structure of a CXC chemokine-receptor fragment in complex with interleukin-8."Structure 7:157-168(1999) [PubMed] [Europe PMC] [Abstract]
- "Crystallization of human interleukin-8. A protein chemotactic for neutrophils and T-lymphocytes."J. Biol. Chem. 265:6851-6853(1990) [PubMed] [Europe PMC] [Abstract]
- "Comparison of the solution nuclear magnetic resonance and crystal structures of interleukin-8. Possible implications for the mechanism of receptor binding."J. Mol. Biol. 217:611-620(1991) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of interleukin 8: symbiosis of NMR and crystallography."Proc. Natl. Acad. Sci. U.S.A. 88:502-506(1991) [PubMed] [Europe PMC] [Abstract]
- "Receptor-binding conformation of the 'ELR' motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 A resolution."Proteins 38:361-367(2000) [PubMed] [Europe PMC] [Abstract]