≡

Selectin, Leukocyte (SELL)

[Edit]

CD62L; L-Selectin; SEL-L; LAM1; LECAM1; LNHR; LSEL; LYAM1; Leu-8; Lyam-1; PLNHR; TQ1; HLHRc; MEL14; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor

Selectin, Leukocyte (SELL)
CCC A086
HGNC 10720
MGI 98279
PubMed 9446670
RGD 3655
UniProt P14151
Wiki L-selectin

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.The protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats.

L-selectin acts as a "homing receptor" for leukocytes to enter tissues at the site of inflammation. Ligands present on endothelial cells will bind to leukocytes expressing L-selectin, causing them to become localised at that point. The receptor is also found on the cell surfaces of "naive" T cells, which have not yet encountered their specific antigen. This surface expression is lost after the cells are activated.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA086Hu01 Recombinant Selectin, Leukocyte (SELL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA086Hu02 Recombinant Selectin, Leukocyte (SELL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA086Hu01 Polyclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
MAA086Hu22 Monoclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
Assay Kits SEA086Hu ELISA Kit for Selectin, Leukocyte (SELL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA086Mu01 Recombinant Selectin, Leukocyte (SELL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA086Mu02 Recombinant Selectin, Leukocyte (SELL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA086Mu01 Polyclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
PAA086Mu02 Polyclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
Assay Kits SEA086Mu ELISA Kit for Selectin, Leukocyte (SELL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA086Ra01 Recombinant Selectin, Leukocyte (SELL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA086Ra01 Polyclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
MAA086Ra21 Monoclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
Assay Kits SEA086Ra ELISA Kit for Selectin, Leukocyte (SELL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA086Ra CLIA Kit for Selectin, Leukocyte (SELL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA086Bo01 Recombinant Selectin, Leukocyte (SELL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA086Bo01 Polyclonal Antibody to Selectin, Leukocyte (SELL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Selectin, Leukocyte (SELL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selectin, Leukocyte (SELL) ELISA Kit Customized Service Offer
  1. "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains."Proc. Natl. Acad. Sci. U.S.A. 86:5562-5566(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins."J. Exp. Med. 170:123-133(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor."Nature 342:78-82(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a human homologue of the murine peripheral lymph node homing receptor."J. Cell Biol. 109:421-427(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils."J. Biol. Chem. 265:7760-7767(1990) [PubMed] [Europe PMC] [Abstract]
  6. Thesis (1998), Freie Universtiaet Berlin, Germany
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51."J. Biol. Chem. 278:37-47(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin."J. Biol. Chem. 278:26391-26400(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A template for generation and comparison of three-dimensional selectin models."Biochem. Biophys. Res. Commun. 216:1018-1023(1995) [PubMed] [Europe PMC] [Abstract]