Monocyte Chemotactic Protein 2 (MCP2)
[Edit]CCL8; CCL-8; SCYA8; MCP-2; HC14; Chemokine C-C-Motif Ligand 8; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 8; Monocyte Chemoattractant Protein 2
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Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2).
The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors.These receptors include CCR1, CCR2B and CCR5.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA088Hu01 | Recombinant Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA088Hu01 | Active Monocyte Chemotactic Protein 2 (MCP2) | Cell culture; Activity Assays. | |
| Antibodies | PAA088Hu01 | Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. |
| MAA088Hu22 | Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA088Hu | ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA088Mu01 | Recombinant Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA088Mu01 | Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Monocyte Chemotactic Protein 2 (MCP2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA088Ca01 | Recombinant Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA088Ca61 | Eukaryotic Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA088Ca61 | Active Monocyte Chemotactic Protein 2 (MCP2) | Cell culture; Activity Assays. | |
| Antibodies | PAA088Ca01 | Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. |
| MAA088Ca21 | Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA088Ca | ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA088Po01 | Recombinant Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA088Po01 | Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. |
| MAA088Po21 | Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA088Po | ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA088Bo01 | Recombinant Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA088Bo01 | Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. |
| MAA088Bo21 | Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA088Bo | ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA088Eq01 | Recombinant Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA088Eq61 | Eukaryotic Monocyte Chemotactic Protein 2 (MCP2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA088Eq61 | Active Monocyte Chemotactic Protein 2 (MCP2) | Cell culture; Activity Assays. | |
| Antibodies | PAA088Eq01 | Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) | WB; IHC; ICC; IP. |
| Assay Kits | SEA088Eq | ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]
- "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
- "Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor."J. Immunol. 160:4034-4041(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors."Biochemistry 39:14075-14081(2000) [PubMed] [Europe PMC] [Abstract]