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Colony Stimulating Factor 1, Macrophage (MCSF)

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CSF1; M-CSF; Lanimostim; Processed macrophage colony-stimulating factor 1

Colony Stimulating Factor 1, Macrophage (MCSF)
CCC A090
HGNC 2432
MGI 1339753
PubMed 12379904
RGD 621063
UniProt P09603
Wiki M-CSF

Colony-stimulating factors (CSFs) are secreted glycoproteins which bind to receptor proteins on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which can cause the cells to proliferate and differentiate into a specific kind of blood cell. The substance which was found to stimulate formation of colonies of macrophages, for instance, was called macrophage colony-stimulating factor, and so on.

Macrophage Colony-stimulating factor is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types.The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA090Hu01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA090Hu01 Active Colony Stimulating Factor 1, Macrophage (MCSF) Cell culture; Activity Assays.
RPA090Hu02 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
EPA090Hu61 Eukaryotic Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
EPA090Hu62 Eukaryotic Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA090Hu02 Active Colony Stimulating Factor 1, Macrophage (MCSF) Cell culture; Activity Assays.
Antibodies PAA090Hu01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
MAA090Hu22 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
Assay Kits SEA090Hu ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA090Mu01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA090Mu02 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA090Mu01 Active Colony Stimulating Factor 1, Macrophage (MCSF) Cell culture; Activity Assays.
EPA090Mu61 Eukaryotic Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA090Mu03 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA090Mu61 Active Colony Stimulating Factor 1, Macrophage (MCSF) Cell culture; Activity Assays.
Antibodies PAA090Mu01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAA090Mu02 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
Assay Kits SEA090Mu ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA090Ra01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA090Ra01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
MAA090Ra21 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
Assay Kits SEA090Ra ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) Polyclonal Antibody Customized Service Offer
Assay Kits SEA090Po ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein." Science 235:1504-1508(1987) [PubMed] [Europe PMC] [Abstract]
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  10. "The structure of recombinant human carboxy-terminal-truncated macrophage colony-stimulating factor derived from mammalian cells."J. Biochem. 114:255-262(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition."FEBS Lett. 222:341-344(1987) [PubMed] [Europe PMC] [Abstract]
  12. "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis."Biochem. Biophys. Res. Commun. 152:1401-1409(1988) [PubMed] [Europe PMC] [Abstract]
  13. "Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes."Mol. Cell. Biol. 7:2378-2387(1987) [PubMed] [Europe PMC] [Abstract]
  14. "Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs."Mol. Cell. Biol. 8:5026-5034(1988) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species."J. Biol. Chem. 267:4345-4348(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage colony stimulating factor using fast atom bombardment mass spectrometry."Biochemistry 32:482-488(1993) [PubMed] [Europe PMC] [Abstract]
  17. "CSF-1 regulation of the wandering macrophage: complexity in action."Trends Cell Biol. 14:628-638(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Colony-stimulating factor-1 in immunity and inflammation."Curr. Opin. Immunol. 18:39-48(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies."Int. Immunopharmacol. 8:1354-1376(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor."Cancer Res. 69:9498-9506(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."Cytokine 52:215-220(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."J. Leukoc. Biol. 88:495-505(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  24. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  25. "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor."Science 258:1358-1362(1992) [PubMed] [Europe PMC] [Abstract]