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Betacellulin(BTC),has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.Watanabe et al. purified soluble forms of human BTC to homogeneity from the conditioned medium of mouse A9 cells transfected with the human BTC precursor cDNA. Three types of soluble BTC, apparently derived from a single gene, were identified and their biologic activities assessed.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA112Hu01 | Recombinant Betacellulin (bTC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA112Hu01 | Active Betacellulin (bTC) | Cell culture; Activity Assays. | |
| Antibodies | PAA112Hu01 | Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. |
| MAA112Hu22 | Monoclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. | |
| LAA112Hu71 | Biotin-Linked Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC. | |
| Assay Kits | SEA112Hu | ELISA Kit for Betacellulin (bTC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA112Mu01 | Recombinant Betacellulin (bTC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA112Mu02 | Recombinant Betacellulin (bTC) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA112Mu01 | Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. |
| LAA112Mu71 | Biotin-Linked Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC. | |
| LAA112Mu81 | FITC-Linked Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IF. | |
| PAA112Mu02 | Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA112Mu | ELISA Kit for Betacellulin (bTC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA112Ra01 | Recombinant Betacellulin (bTC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA112Ra01 | Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Betacellulin (bTC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Betacellulin (bTC) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA112Bo01 | Recombinant Betacellulin (bTC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA112Bo01 | Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Betacellulin (bTC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Betacellulin (bTC) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA112Ga01 | Recombinant Betacellulin (bTC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA112Ga01 | Polyclonal Antibody to Betacellulin (bTC) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Betacellulin (bTC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Betacellulin (bTC) | ELISA Kit Customized Service Offer |
- "Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family."Biochem. Biophys. Res. Commun. 190:1173-1179(1993) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction."J. Biol. Chem. 269:9966-9973(1994) [PubMed] [Europe PMC] [Abstract]
- "Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form."Growth Factors 13:181-191(1996) [PubMed] [Europe PMC] [Abstract]
- "Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta."Oncogene 12:345-353(1996) [PubMed] [Europe PMC] [Abstract]
- "Ligand discrimination in signaling through an ErbB4 receptor homodimer."J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]
- "Solution structure of betacellulin, a new member of EGF-family ligands."Biochem. Biophys. Res. Commun. 294:1040-1046(2002) [PubMed] [Europe PMC] [Abstract]