TIMP2, is a member of the TIMP family. The proteins are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Mu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA128Mu02 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAA128Mu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
PAA128Mu02 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. | |
Assay Kits | SEA128Mu | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Ra01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA128Ra01 | Active Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Cell culture; Activity Assays. | |
Antibodies | PAA128Ra01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
LAA128Ra71 | Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC. | |
LAA128Ra81 | FITC-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
MAA128Ra21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. | |
Assay Kits | SEA128Ra | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Cavia (Guinea pig )
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Gu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA128Gu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | ELISA Kit Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Rb01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA128Rb51 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Ca01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA128Ca01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
LAA128Ca71 | Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC. | |
Assay Kits | n/a | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Po01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA128Po01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
MAA128Po21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. | |
Assay Kits | SEA128Po | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Bo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA128Bo01 | Active Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Cell culture; Activity Assays. | |
Antibodies | PAA128Bo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
MAA128Bo21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. | |
Assay Kits | SEA128Bo | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Eq01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA128Eq01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
LAA128Eq71 | Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC. | |
MAA128Eq21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. | |
Assay Kits | SEA128Eq | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Ga01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA128Ga01 | Active Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Cell culture; Activity Assays. | |
Antibodies | PAA128Ga01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | ELISA Kit Customized Service Offer |
Organism species: Danio rerio (Zebrafish)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA128Fi01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA128Fi01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | ELISA Kit Customized Service Offer |
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- "Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity."J. Cancer Res. Clin. Oncol. 127:653-658(2001) [PubMed] [Europe PMC] [Abstract]
- "Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family."Biochemistry 33:11745-11759(1994) [PubMed] [Europe PMC] [Abstract]
- "High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3."J. Biol. Chem. 273:21736-21743(1998) [PubMed] [Europe PMC] [Abstract]
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- "Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2."Proc. Natl. Acad. Sci. U.S.A. 99:7414-7419(2002) [PubMed] [Europe PMC] [Abstract]