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Transforming Growth Factor Beta Induced Protein (TGFbI)

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TGF-BI; CSD3; LCD1; CSD1; CSD2; BIGH3; CDB1; CDGG1; RGD-CAP; Kerato-Epithelin; RGD-Containing Collagen-Associated Protein

Transforming Growth Factor Beta Induced Protein (TGFbI)
CCC A131
HGNC 11771
MGI 99959
PubMed 16683255
RGD TGFBI
UniProt Q15582
Wiki TGFBI
Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which is encoded by the TGFBI gene.
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations of the gene cause several forms of corneal dystrophies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA131Hu01 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA131Hu01 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC
MAA131Hu22 Monoclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
Assay Kits SEA131Hu ELISA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA131Hu CLIA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA131Mu01 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
RPA131Mu02 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA131Mu01 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
PAA131Mu02 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
Assay Kits SEA131Mu ELISA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA131Mu CLIA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA131Rb01 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA131Rb51 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA131Po01 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA131Po01 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA131Bo01 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA131Bo01 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA131Fi01 Recombinant Transforming Growth Factor Beta Induced Protein (TGFbI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA131Fi01 Polyclonal Antibody to Transforming Growth Factor Beta Induced Protein (TGFbI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta Induced Protein (TGFbI) ELISA Kit Customized Service Offer
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  9. "Mutation hot spots in 5q31-linked corneal dystrophies."Am. J. Hum. Genet. 62:320-324(1998) [PubMed] [Europe PMC] [Abstract]
  10. "A kerato-epithelin (beta-ig-h3) mutation in lattice corneal dystrophy type IIIA."Am. J. Hum. Genet. 62:719-722(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Two distinct kerato-epithelin mutations in Reis-Bucklers corneal dystrophy."Am. J. Ophthalmol. 126:535-542(1998) [PubMed] [Europe PMC] [Abstract]
  12. "A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities."Hum. Genet. 103:286-289(1998) [PubMed] [Europe PMC] [Abstract]
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  14. "Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesis."Hum. Mutat. 14:126-132(1999) [PubMed] [Europe PMC] [Abstract]
  15. "A mutation within exon 14 of the TGFBI (BIGH3) gene on chromosome 5q31 causes an asymmetric, late-onset form of lattice corneal dystrophy."Ophthalmology 106:964-970(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Association of autosomal dominantly inherited corneal dystrophies with BIGH3 gene mutations in Japan."Am. J. Ophthalmol. 130:516-517(2000) [PubMed] [Europe PMC] [Abstract]
  17. "A novel variant of granular corneal dystrophy caused by association of 2 mutations in the TGFBI gene-R124L and deltaT125-deltaE126."Arch. Ophthalmol. 118:814-818(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Corneal amyloidosis caused by Leu518Pro mutation of betaig-h3 gene."Br. J. Ophthalmol. 84:583-585(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Late-onset form of lattice corneal dystrophy caused by Leu527Arg mutation of the TGFBI gene."Cornea 20:525-529(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Histologic phenotype-genotype correlation of corneal dystrophies associated with eight distinct mutations in the TGFBI gene."Ophthalmology 108:818-823(2001) [PubMed] [Europe PMC] [Abstract]
  21. "BIGH3 mutation spectrum in corneal dystrophies."Invest. Ophthalmol. Vis. Sci. 43:949-954(2002) [PubMed] [Europe PMC] [Abstract]
  22. "A new mutation (Leu569Arg) within exon 13 of the TGFBI (BIGH3) gene causes lattice corneal dystrophy type I."Am. J. Ophthalmol. 136:872-878(2003) [PubMed] [Europe PMC] [Abstract]
  23. "A novel mutation of the TGFBI gene found in a Vietnamese family with atypical granular corneal dystrophy."Jpn. J. Ophthalmol. 47:246-248(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI gene."Am. J. Ophthalmol. 138:772-781(2004) [PubMed] [Europe PMC] [Abstract]
  25. "TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients."Invest. Ophthalmol. Vis. Sci. 46:121-125(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin."Invest. Ophthalmol. Vis. Sci. 46:1133-1139(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type I."Jpn. J. Ophthalmol. 49:84-88(2005) [PubMed] [Europe PMC] [Abstract]
  28. "A subset of patients with epithelial basement membrane corneal dystrophy have mutations in TGFBI/BIGH3."Hum. Mutat. 27:553-557(2006) [PubMed] [Europe PMC] [Abstract]
  29. "A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I."Jpn. J. Ophthalmol. 50:403-408(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Unilateral lattice corneal dystrophy associated with the novel His572del mutation in the TGFBI gene."Mol. Vis. 12:142-146(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Expanding the mutational spectrum in TGFBI-linked corneal dystrophies: identification of a novel and unusual mutation (Val113Ile) in a family with granular dystrophy."Mol. Vis. 12:331-335(2006) [PubMed] [Europe PMC] [Abstract]