Thrombopoietin (TPO)
[Edit]THPO; MGDF; MKCSF; ML; MPLLG; Myeloproliferative Leukemia Virus Oncogene Ligand; Megakaryocyte Growth And Development Factor; Megakaryocyte Stimulating Factor
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Thrombopoietin (TPO), is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitroand in vivo. TPO has been purified and cloned from several species including mouse, rat, and dog. The proteins from the various species are highly conserved, exhibiting from 69-75% sequence identity at the amino acid sequence level. Mature TPO can be divided into two domains: the amino-terminal half with homology to erythropoietin (Epo) and the carboxy-terminal half rich in serine, threonine and proline residues and containing seven potential N-linked glycosylation sites. The carboxy terminus domain of TPO has been shown to regulate the specific activity and circulating half-life of TPO. The carboxy-terminal may also have a role in promoting the efficient biosynthesis and secretion of TPO.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Hu01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA135Hu02 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA135Hu03 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA135Hu04 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA135Hu01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| MAA135Hu22 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. | |
| PAA135Hu02 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA135Hu | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA135Hu | CLIA Kit for Thrombopoietin (TPO) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Mu01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA135Mu02 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA135Mu01 | Active Thrombopoietin (TPO) | Cell culture; Activity Assays. | |
| APA135Mu61 | Active Thrombopoietin (TPO) | Cell culture; Activity Assays. | |
| Antibodies | PAA135Mu01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAA135Mu02 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA135Mu | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Ra01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA135Ra01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| MAA135Ra21 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA135Ra | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Ca01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA135Ca01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| MAA135Ca21 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA135Ca | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Po01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA135Po02 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA135Po03 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA135Po01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Thrombopoietin (TPO) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Thrombopoietin (TPO) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Bo01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA135Bo01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| MAA135Bo21 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA135Bo | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA135Ga01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA135Ga01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Thrombopoietin (TPO) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Thrombopoietin (TPO) | ELISA Kit Customized Service Offer |
- "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand."Nature 369:533-538(1994) [PubMed] [Europe PMC] [Abstract]
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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- "Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246."Biochemistry 35:14849-14861(1996) [PubMed] [Europe PMC] [Abstract]
- "Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment."Proc. Natl. Acad. Sci. U.S.A. 101:1816-1821(2004) [PubMed] [Europe PMC] [Abstract]