Tumor Necrosis Factor Receptor Superfamily, Member 10C (TNFRSF10C)

TRAILR3, a novel member of the TRAIL receptor family. Although the open reading frame potentially encoded a 299-amino acid protein, the authors suggested that translation begins at amino acid 41, yielding a protein of 259 amino acids. TRAILR3 contains a predicted signal sequence, 2 of the 4 cysteine-rich pseudorepeats characteristic of the extracellular domain of members of the TNF receptor family, an extracellular linker sequence, and a short, hydrophobic C-terminal sequence. Transient expression studies showed that TRAILR3 is a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. In contrast to TRAILR1 and TRAILR2, TRAILR3 appears to be glycosylphosphatidylinositol-linked and lacks a cytoplasmic region, including the death domain.