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Plasminogen Activator, Urokinase (uPA)

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PLAU; ATF; URK; UK; UP-A; Abbokinase; Urokinase-Type Plasminogen Activator

Plasminogen Activator, Urokinase (uPA)
CCC A140
HGNC 9052
MGI 97611
PubMed 19200050
RGD 3343
UniProt P00749
Wiki Urokinase

Urokinase-type plasminogen activator is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Hu01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
APA140Hu61 Active Plasminogen Activator, Urokinase (uPA) Cell culture; Activity Assays.
EPA140Hu61 Eukaryotic Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA140Hu01 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
MAA140Hu22 Monoclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits SEA140Hu ELISA Kit for Plasminogen Activator, Urokinase (uPA) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA140Hu CLIA Kit for Plasminogen Activator, Urokinase (uPA) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Mu01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA140Mu02 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
APA140Mu61 Active Plasminogen Activator, Urokinase (uPA) Cell culture; Activity Assays.
APA140Mu62 Active Plasminogen Activator, Urokinase (uPA) Cell culture; Activity Assays.
Antibodies PAA140Mu01 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
PAA140Mu02 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits SEA140Mu ELISA Kit for Plasminogen Activator, Urokinase (uPA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Ra01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA140Ra01 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
MAA140Ra21 Monoclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits SEA140Ra ELISA Kit for Plasminogen Activator, Urokinase (uPA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Rb01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA140Rb51 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Plasminogen Activator, Urokinase (uPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plasminogen Activator, Urokinase (uPA) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Po01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA140Po02 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA140Po03 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA140Po01 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
MAA140Po21 Monoclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits SEA140Po ELISA Kit for Plasminogen Activator, Urokinase (uPA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Bo01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA140Bo01 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
MAA140Bo21 Monoclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
MAA140Bo22 Monoclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
MAA140Bo23 Monoclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits SEA140Bo ELISA Kit for Plasminogen Activator, Urokinase (uPA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA140Ga01 Recombinant Plasminogen Activator, Urokinase (uPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA140Ga01 Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Plasminogen Activator, Urokinase (uPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plasminogen Activator, Urokinase (uPA) ELISA Kit Customized Service Offer
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  26. "(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase."Proc. Natl. Acad. Sci. U.S.A. 97:5113-5118(2000) [PubMed] [Europe PMC] [Abstract]
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  29. ErratumThromb. Haemost. 78:973-973(1997)
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  31. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]