Meprin A Alpha (MEP1a)

[Edit]

PPHA; PABA Peptide Hydrolase; Endopeptidase-2; N-benzoyl-L-tyrosyl-P-amino-Benzoic Acid Hydrolase Subunit Alpha; PABA Peptide Hydrolase

Meprin A Alpha (MEP1a)
Meprins, members of the 'astacin family' of metalloendopeptidases, are capable of hydrolyzing a variety of peptide and protein substrates. Two forms of meprins, designated A and B. Meprin A (EC 3.4.24.18) is the best characterized of the meprins and is known to hydrolyze peptides such as bradykinin, melanocyte-stimulating hormone, neurotensin, luteinizing hormone releasing hormone, transforming growth factor-alpha, and parathyroid hormone. Meprin B from mouse kidney has latent proteolytic activity against polypeptide substrates. Rat meprin A is sometimes referred to as endopeptidase-2 or endopeptidase-24.18; human meprin A is also called N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA peptide) hydrolase (PPH).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA171Hu01 Recombinant Meprin A Alpha (MEP1a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA171Hu01 Polyclonal Antibody to Meprin A Alpha (MEP1a) WB; IHC; ICC; IP.
MAA171Hu22 Monoclonal Antibody to Meprin A Alpha (MEP1a) WB; IHC; ICC; IP.
Assay Kits CEA171Hu ELISA Kit for Meprin A Alpha (MEP1a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA171Mu01 Recombinant Meprin A Alpha (MEP1a) Positive Control; Immunogen; SDS-PAGE; WB.
RPA171Mu02 Recombinant Meprin A Alpha (MEP1a) Positive Control; Immunogen; SDS-PAGE; WB.
CPA171Mu21 OVA Conjugated Meprin A Alpha (MEP1a) Immunogen; SDS-PAGE; WB.
Antibodies PAA171Mu01 Polyclonal Antibody to Meprin A Alpha (MEP1a) WB; IHC; ICC; IP.
PAA171Mu02 Polyclonal Antibody to Meprin A Alpha (MEP1a) WB; IHC; ICC; IP.
PAA171Mu08 Polyclonal Antibody to Meprin A Alpha (MEP1a) WB; IHC; ICC; IP.
Assay Kits CEA171Mu ELISA Kit for Meprin A Alpha (MEP1a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA171Ra01 Recombinant Meprin A Alpha (MEP1a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Meprin A Alpha (MEP1a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Meprin A Alpha (MEP1a) Polyclonal Antibody Customized Service Offer
Assay Kits CEA171Ra ELISA Kit for Meprin A Alpha (MEP1a) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells."FEBS Lett. 335:367-375(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities."Biol. Chem. 388:1163-1172(2007) [PubMed] [Europe PMC] [Abstract]