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Importin 8 (IPO8)

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RANBP8; RAN Binding Protein 8

Importin 8 (IPO8)
CCC A206
HGNC 9853
MGI 2444611
PubMed 19014639
UniProt O15397
Importin 8 is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase.
Human RANBP8 and Xenopus RanBP7 share 61% amino acid identity. They both belong to a Ran-binding protein superfamily whose members share with importin-beta an N-terminal sequence motif that appears to account for RanGTP binding. IPO8 was required for AGO2 binding to a large set of target mRNAs, and knockdown of IPO8 led to a moderate increase of target mRNAs. Knockdown of IPO8 had no effect on AGO stability, miRNA biogenesis, or miRNA loading onto AGO proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 8 (IPO8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 8 (IPO8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 8 (IPO8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 8 (IPO8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 8 (IPO8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA206Mu01 Recombinant Importin 8 (IPO8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA206Mu01 Polyclonal Antibody to Importin 8 (IPO8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Importin 8 (IPO8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 8 (IPO8) ELISA Kit Customized Service Offer
  1. "A novel class of RanGTP binding proteins."J. Cell Biol. 138:65-80(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin."J. Cell Sci. 114:3479-3485(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]