Transcription factor 20 (TCF20)
[Edit]AR1; SPBP; Stromelysin-1 Platelet-Derived Growth Factor-Responsive Element Binding Protein; Stromelysin-1 PDGF-responsive element-binding protein; SPRE-binding protein
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Transcription factor 20 is a protein binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.
Sanz et al. (1995) found that expression of SPBP in mammalian cells activated transcription of a reporter gene construct containing either the full-length stromelysin promoter or a single copy of the SPRE inserted upstream of a heterologous promoter.Rajadhyaksha et al. (1998) identified cDNAs encoding AR1, a human SPBP homolog.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transcription factor 20 (TCF20) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transcription factor 20 (TCF20) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transcription factor 20 (TCF20) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transcription factor 20 (TCF20) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transcription factor 20 (TCF20) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Transcription factor 20 (TCF20) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Transcription factor 20 (TCF20) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Transcription factor 20 (TCF20) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Transcription factor 20 (TCF20) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transcription factor 20 (TCF20) | ELISA Kit Customized Service Offer |
- "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators."J. Biol. Chem. 275:40288-40300(2000) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
- "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
- "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization."Cytogenet. Cell Genet. 81:176-177(1998) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]