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Free Fatty Acid Receptor 3 (FFAR3)

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FFA3R; GPR41; G Protein-Coupled Receptor 41

Free Fatty Acid Receptor 3 (FFAR3)
CCC A226
HGNC 4499
MGI 2685324
PubMed 24325907
RGD 1311035
UniProt O14843
Wiki FFA3
The physiologic responses to galanin (GAL) are mediated through specific membrane receptors called GALRs, which are members of the G protein-coupled receptor (GPCR) family. Sawzdargo et al. (1997) amplified human genomic DNA using PCR with degenerate primers based on conserved sequences of human and rat GALR1 and rat Galr2 .
The GPR41 gene has no introns. GPR41 encodes a predicted 346-amino acid GPCR containing 7 transmembrane domains, 1 glycosylation site, 1 PKC phosphorylation site, 2 PKA/PKC phosphorylation sites, and 1 palmitoylation site, which is located in the C-terminal domain. The GPR41 protein shares 98% amino acid identity with GPR42 but little similarity with GALRs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Free Fatty Acid Receptor 3 (FFAR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Free Fatty Acid Receptor 3 (FFAR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Free Fatty Acid Receptor 3 (FFAR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Free Fatty Acid Receptor 3 (FFAR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Free Fatty Acid Receptor 3 (FFAR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA226Mu01 Recombinant Free Fatty Acid Receptor 3 (FFAR3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA226Mu02 Recombinant Free Fatty Acid Receptor 3 (FFAR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA226Mu01 Polyclonal Antibody to Free Fatty Acid Receptor 3 (FFAR3) WB; IHC; ICC; IP.
PAA226Mu02 Polyclonal Antibody to Free Fatty Acid Receptor 3 (FFAR3) WB; IHC; ICC; IP.
Assay Kits SEA226Mu ELISA Kit for Free Fatty Acid Receptor 3 (FFAR3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Free Fatty Acid Receptor 3 (FFAR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Free Fatty Acid Receptor 3 (FFAR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Free Fatty Acid Receptor 3 (FFAR3) Polyclonal Antibody Customized Service Offer
Assay Kits SEA226Ra ELISA Kit for Free Fatty Acid Receptor 3 (FFAR3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids." J. Biol. Chem. 278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation."J. Biol. Chem. 278:25481-25489(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids."J. Biol. Chem. 283:32913-32924(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42."DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)."Proc. Natl. Acad. Sci. U.S.A. 108:8030-8035(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3."J. Biol. Chem. 287:41195-41209(2012) [PubMed] [Europe PMC] [Abstract]