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Linker For Activation Of T-Cell (LAT)

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LAT1; Pp36; Linker Of Activated T Cells; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein

Linker For Activation Of T-Cell (LAT)
CCC A270
HGNC 18874
MGI 1342293
PubMed 10233842
RGD 620802
UniProt O43561
Wiki LAT

Linker of Activated T cells also known as LAT is a protein which is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.

The protein encoded by this gene is phosphorylated by ZAP70/SYK protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts (also known as glycosphingolipid-enriched microdomains or GEMs) and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA270Hu01 Recombinant Linker For Activation Of T-Cell (LAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA270Hu01 Polyclonal Antibody to Linker For Activation Of T-Cell (LAT) WB; IHC; ICC; IP.
MAA270Hu22 Monoclonal Antibody to Linker For Activation Of T-Cell (LAT) WB; IHC; ICC; IP.
Assay Kits SEA270Hu ELISA Kit for Linker For Activation Of T-Cell (LAT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA270Mu01 Recombinant Linker For Activation Of T-Cell (LAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA270Mu01 Polyclonal Antibody to Linker For Activation Of T-Cell (LAT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Linker For Activation Of T-Cell (LAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Linker For Activation Of T-Cell (LAT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA270Ra01 Recombinant Linker For Activation Of T-Cell (LAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA270Ra01 Polyclonal Antibody to Linker For Activation Of T-Cell (LAT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Linker For Activation Of T-Cell (LAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Linker For Activation Of T-Cell (LAT) ELISA Kit Customized Service Offer
  1. "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation."Cell 92:83-92(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells."J. Exp. Med. 187:1157-1161(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation."Immunity 9:239-246(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells."J. Biol. Chem. 274:28050-28057(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity."J. Immunol. 162:2453-2456(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling."J. Biol. Chem. 275:23355-23361(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells."J. Biol. Chem. 275:20480-20487(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin."J. Biol. Chem. 275:33427-33434(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells."Biochem. J. 356:461-471(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation."Mol. Cell. Biol. 21:2393-2403(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav."Biochemistry 41:10732-10740(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling."J. Cell Biol. 162:673-682(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  16. "LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways."Bioessays 26:61-67(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Transmembrane adaptor molecules: a new category of lymphoid-cell markers."Blood 107:213-221(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]