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Integrin Alpha D (ITGaD)

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CD11d; CD11-D; ITG-AD; ADB2; ITGA-D; CD11 antigen-like family member D; Leukointegrin alpha D

Integrin Alpha D (ITGaD)
CCC A271
HGNC 6146
MGI 3578624
PubMed 9598326
RGD 71075
UniProt Q13349
Wiki ITGAD

Three ITGs that share the beta-2 (CD18) subunit are restricted in expression to leukocytes and have homologous alpha subunits: alpha-L (ITGAL), alpha-M (ITGAM), and alpha-X (ITGAX). Wong designed degenerate PCR primers to identify novel leukocyte integrin alpha subunits. In this way they isolated a partial genomic clone encoding a new alpha subunit, designated ITGAD.

The ITGAD gene was found to be highly homologous to the 3 previously known alpha-subunit-encoding genes in deduced amino acid sequence, intron/exon structure, and chromosomal location. The ITGAD gene localize to 16p11.2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA271Hu01 Recombinant Integrin Alpha D (ITGaD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA271Hu01 Polyclonal Antibody to Integrin Alpha D (ITGaD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha D (ITGaD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha D (ITGaD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA271Mu01 Recombinant Integrin Alpha D (ITGaD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA271Mu01 Polyclonal Antibody to Integrin Alpha D (ITGaD) WB; IHC; ICC; IP.
LAA271Mu71 Biotin-Linked Polyclonal Antibody to Integrin Alpha D (ITGaD) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Integrin Alpha D (ITGaD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha D (ITGaD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA271Ra01 Recombinant Integrin Alpha D (ITGaD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA271Ra01 Polyclonal Antibody to Integrin Alpha D (ITGaD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha D (ITGaD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha D (ITGaD) ELISA Kit Customized Service Offer
  1. "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3."Immunity 3:683-690(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3."J. Biol. Chem. 275:8959-8969(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit."Gene 171:291-294(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)."J. Exp. Med. 188:2187-2191(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1."J. Immunol. 163:1984-1990(1999) [PubMed] [Europe PMC] [Abstract]