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Transportin 1 (TNPO1)

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MIP1; IPO2; KPNB2; MIP; MIP1; TRN; M9 region interaction protein 1; Importin 2; Karyopherin Beta 2

Transportin 1 (TNPO1)
CCC A272
HGNC 6401
MGI 2681523
PubMed 22842875
RGD 1308372
UniProt Q92973
Wiki Transportin_1

Targeting of most nuclear proteins to the cell nucleus is initiated by interaction between the protein's nuclear localization signal (NLS) and the importin, or karyopherin, receptor complex. An importin heterodimer recognizes the NLS protein in the cytoplasm via its alpha subunit and, via its beta subunit, docks the complex to a subset of peptide repeat-containing proteins known as nucleoporins.

Transportin-1 is  the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA272Hu01 Recombinant Transportin 1 (TNPO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA272Hu01 Polyclonal Antibody to Transportin 1 (TNPO1) WB; IHC; ICC; IP.
MAA272Hu22 Monoclonal Antibody to Transportin 1 (TNPO1) WB; IHC; ICC; IP.
Assay Kits SEA272Hu ELISA Kit for Transportin 1 (TNPO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA272Mu01 Recombinant Transportin 1 (TNPO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA272Mu01 Polyclonal Antibody to Transportin 1 (TNPO1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transportin 1 (TNPO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transportin 1 (TNPO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transportin 1 (TNPO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transportin 1 (TNPO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transportin 1 (TNPO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transportin 1 (TNPO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transportin 1 (TNPO1) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA272Bo01 Recombinant Transportin 1 (TNPO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA272Bo01 Polyclonal Antibody to Transportin 1 (TNPO1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transportin 1 (TNPO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transportin 1 (TNPO1) ELISA Kit Customized Service Offer
  1. "A novel receptor-mediated nuclear protein import pathway."Cell 86:985-994(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Karyopherin beta2 mediates nuclear import of a mRNA binding protein."Proc. Natl. Acad. Sci. U.S.A. 94:5055-5060(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Transportin: nuclear transport receptor of a novel nuclear protein import pathway."Exp. Cell Res. 229:261-266(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor."Biochim. Biophys. Acta 1396:51-56(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin."J. Cell Sci. 114:3479-3485(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors."J. Cell Sci. 122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract]
  13. "RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1."Mol. Cell. Biol. 29:1487-1497(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp."Nature 399:230-237(1999) [PubMed] [Europe PMC] [Abstract]