Calnexin (CNX)
[Edit]CANX; CNX; IP90; P90; Major Histocompatibility Complex Class I Antigen-Binding Protein p88
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Calnexin is a 90kDa integral protein of the endoplasmic reticulum. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short, acidic cytoplasmic tail. Calnexin is one of the chaperone molecules, which are characterized by their main function of assisting protein folding and quality control, ensuring that only properly folded and assembled proteins proceed further along the secretory pathway. Oligosaccharides with three sequential glucose residues are added to asparagine residues of the nascent proteins in the ER. The monoglucosylated oligosaccharides that are recognized by calnexin result from the trimming of two glucose residues by the sequential action of two glucosidases, I and II.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA280Hu01 | Recombinant Calnexin (CNX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA280Hu01 | Polyclonal Antibody to Calnexin (CNX) | WB; IHC; ICC; IP. |
| MAA280Hu22 | Monoclonal Antibody to Calnexin (CNX) | WB; IHC; ICC; IP. | |
| CAA280Hu22 | Anti-Calnexin (CNX) Monoclonal Antibody | Loading Control of WB. | |
| CAA280Hu01 | Anti-Calnexin (CNX) Polyclonal Antibody | Loading Control of WB. | |
| MAA280Hu21 | Monoclonal Antibody to Calnexin (CNX) | WB; IHC; ICC; IP. | |
| MAA280Hu23 | Monoclonal Antibody to Calnexin (CNX) | WB,IHC,ICC/IF | |
| MAA280Hu24 | Monoclonal Antibody to Calnexin (CNX) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA280Hu | ELISA Kit for Calnexin (CNX) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA280Mu01 | Recombinant Calnexin (CNX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA280Mu03 | Recombinant Calnexin (CNX) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA280Mu04 | Recombinant Calnexin (CNX) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA280Mu01 | Polyclonal Antibody to Calnexin (CNX) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Calnexin (CNX) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Calnexin (CNX) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Calnexin (CNX) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Calnexin (CNX) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Calnexin (CNX) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Calnexin (CNX) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Calnexin (CNX) | ELISA Kit Customized Service Offer |
- "Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)."J. Biol. Chem. 268:9585-9592(1993) [PubMed] [Europe PMC] [Abstract]
- "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5."Biochemistry 33:3229-3236(1994) [PubMed] [Europe PMC] [Abstract]
- "The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin."Electrophoresis 15:482-490(1994) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]