B-Cell Activation Factor Receptor (BAFFR)
[Edit]CD268; TNFRSF13C; TNFRSF13-C; BAFF-R; BAFFR; BR3; Tumor Necrosis Factor Receptor Superfamily Member 13C
-90281.jpg)
BAFF receptor is a recently identified molecule that specifically binds BLyS, a protein belonging to the tumor necrosis factor (TNF) family, and is involved in survival and maturation of B cells. Recent studies have demonstrated that mice defective in BAFF-R gene exhibit an altered profile of the B cell pool, a phenotype observed in BLyS knockout mice as well. These features suggest that mutations in this gene may result in humoral immunodeficiency.
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA281Hu01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA281Hu02 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA281Hu01 | Active B-Cell Activation Factor Receptor (BAFFR) | Cell culture; Activity Assays. | |
| Antibodies | PAA281Hu01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| MAA281Hu22 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. | |
| LAA281Hu81 | FITC-Linked Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| LAA281Hu71 | Biotin-Linked Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC. | |
| PAA281Hu02 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA281Hu | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA281Mu01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA281Mu01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA281Ra01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA281Ra02 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA281Ra01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| LAA281Ra71 | Biotin-Linked Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC. | |
| PAA281Ra02 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA281Ga01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA281Ga01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | ELISA Kit Customized Service Offer |
- "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF."Science 293:2108-2111(2001) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
- "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency."Curr. Biol. 11:1547-1552(2001) [PubMed] [Europe PMC] [Abstract]
- "BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2."Immunity 17:515-524(2002) [PubMed] [Europe PMC] [Abstract]
- "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site."Biochemistry 42:5977-5983(2003) [PubMed] [Europe PMC] [Abstract]
- "Ligand-receptor binding revealed by the TNF family member TALL-1."Nature 423:49-56(2003) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation."Nat. Struct. Biol. 10:342-348(2003) [PubMed] [Europe PMC] [Abstract]
- "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells."Blood 108:3103-3111(2006) [PubMed] [Europe PMC] [Abstract]
- "Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency."J. Clin. Immunol. 25:496-502(2005) [PubMed] [Europe PMC] [Abstract]
- "B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans."Proc. Natl. Acad. Sci. U.S.A. 106:13945-13950(2009) [PubMed] [Europe PMC] [Abstract]