Galectin 12 (GAL12)
[Edit]LGALS12; GRIP1; Lectin,Galactoside-Binding Soluble 12; Galectin-related inhibitor of proliferation
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Galectins constitute a family of proteins that bind to β-galactoside residues and have diverse physiological functions. Report on the identification of a galectin-like molecule, galectin-12, in a human adipose tissue cDNA library. The protein contained two potential carbohydrate-recognition domains with the second carbohydrate-recognition domain being less conserved compared with other galectins.
Galectin-12 mRNA was predominantly expressed in adipose tissue of human and mouse and in differentiated 3T3-L1 adipocytes. Caloric restriction and treatment of obese animals with troglitazone increased galectin-12 mRNA levels and decreased the average size of the cells in adipose tissue.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA312Hu01 | Recombinant Galectin 12 (GAL12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA312Hu01 | Active Galectin 12 (GAL12) | Cell culture; Activity Assays. | |
| Antibodies | PAA312Hu01 | Polyclonal Antibody to Galectin 12 (GAL12) | WB; IHC; ICC; IP. |
| MAA312Hu22 | Monoclonal Antibody to Galectin 12 (GAL12) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA312Hu | ELISA Kit for Galectin 12 (GAL12) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA312Mu01 | Recombinant Galectin 12 (GAL12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA312Mu02 | Recombinant Galectin 12 (GAL12) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA312Mu01 | Active Galectin 12 (GAL12) | Cell culture; Activity Assays. | |
| Antibodies | PAA312Mu01 | Polyclonal Antibody to Galectin 12 (GAL12) | WB; IHC; ICC; IP. |
| PAA312Mu02 | Polyclonal Antibody to Galectin 12 (GAL12) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA312Mu | ELISA Kit for Galectin 12 (GAL12) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA312Ra01 | Recombinant Galectin 12 (GAL12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA312Ra01 | Active Galectin 12 (GAL12) | Cell culture; Activity Assays. | |
| Antibodies | PAA312Ra01 | Polyclonal Antibody to Galectin 12 (GAL12) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Galectin 12 (GAL12) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Galectin 12 (GAL12) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA312Ca01 | Recombinant Galectin 12 (GAL12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA312Ca01 | Active Galectin 12 (GAL12) | Cell culture; Activity Assays. | |
| Antibodies | PAA312Ca01 | Polyclonal Antibody to Galectin 12 (GAL12) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Galectin 12 (GAL12) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Galectin 12 (GAL12) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA312Po01 | Recombinant Galectin 12 (GAL12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA312Po01 | Active Galectin 12 (GAL12) | Cell culture; Activity Assays. | |
| Antibodies | PAA312Po01 | Polyclonal Antibody to Galectin 12 (GAL12) | WB |
| Assay Kits | n/a | CLIA Kit for Galectin 12 (GAL12) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Galectin 12 (GAL12) | ELISA Kit Customized Service Offer |
- "Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity."J. Biol. Chem. 276:34089-34097(2001) [PubMed] [Europe PMC] [Abstract]
- "Cell cycle regulation by galectin-12, a new member of the galectin superfamily."J. Biol. Chem. 276:20252-20260(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]