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X-Ray Repair Cross Complementing 6 (XRCC6)

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Ku70; CTC75; CTCBF; G22P1; ML8; TLAA; Lupus Ku Autoantigen Protein P70; ATP-Dependent DNA Helicase 2 Subunit 1; CTC box-binding factor 75 kDa; Thyroid-lupus autoantigen

X-Ray Repair Cross Complementing 6 (XRCC6)
CCC A316
HGNC 4055
MGI 95606
PubMed 23393345
RGD 2643
UniProt P12956
Wiki XRCC6

Ku is a protein that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to human. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other).

Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. The two Ku subunits form a basket-shaped structure that threads onto the DNA end. Once bound, Ku can slide down the DNA strand, allowing more Ku molecules to thread onto the end.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA316Hu01 Recombinant X-Ray Repair Cross Complementing 6 (XRCC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA316Hu01 Polyclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) WB; IHC; ICC; IP.
MAA316Hu22 Monoclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) WB; IHC; ICC; IP.
Assay Kits SEA316Hu ELISA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA316Hu CLIA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA316Mu01 Recombinant X-Ray Repair Cross Complementing 6 (XRCC6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA316Mu02 Recombinant X-Ray Repair Cross Complementing 6 (XRCC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA316Mu01 Polyclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) WB; IHC; ICC; IP.
PAA316Mu02 Polyclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) WB; IHC; ICC; IP.
Assay Kits SEA316Mu ELISA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA316Mu CLIA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA316Ra01 Recombinant X-Ray Repair Cross Complementing 6 (XRCC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA316Ra01 Polyclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) ELISA Kit Customized Service Offer
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  17. "Defining interactions between DNA-PK and ligase IV/XRCC4."DNA Repair 1:225-235(2002) [PubMed] [Europe PMC] [Abstract]
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  19. "Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment."J. Mol. Biol. 326:93-103(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86."J. Biol. Chem. 279:25241-25250(2004) [PubMed] [Europe PMC] [Abstract]
  21. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  25. "55K isoform of CDK9 associates with Ku70 and is involved in DNA repair."Biochem. Biophys. Res. Commun. 397:245-250(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends."Nature 464:1214-1217(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex."PLoS ONE 7:E33404-E33404(2012) [PubMed] [Europe PMC] [Abstract]
  32. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  33. "DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair."Science 347:185-188(2015) [PubMed] [Europe PMC] [Abstract]
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  35. "Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair."Nature 412:607-614(2001) [PubMed] [Europe PMC] [Abstract]